Multi-mode set integration dielectric characterization apparatus and method of micro-nano biological particle

Abstract

The invention discloses an integrated dielectric representing device of micro-nano biological particles and with multiple modes, which comprises a dielectric representing chip (100), a machine visual device (200), a main control system (300), an actuating signal generating device (400), a virtual electrode projector (500) and a micro displacement worktable (600), wherein, the dielectric representing chip (100) is positioned on the micro displacement worktable (600) and between the machine visual device (200) and the virtual electrode projector (500) in the vertical direction; the machine visual device (200) comprises an elevating table (230) that is controlled by the main control system (300); the main control system (300) obtains data from the machine visual device (200), and simultaneously sends a command signal to the actuating signal generating device (400) and the virtual electrode projector (500). The integrated dielectric representing device of micro-nano biological particles and with multiple modes integrates a light-mode virtual electrode and a spiral body electrode array, and by collecting a particle movement image in real time and detecting the particle suspension height with automatic focusing, the method can all-roundly and precisely measure a dielectric spectrum under three dielectric electrophoresis modes, and can realize the dielectric characteristic diagnosis of severe diseases, with low cost, high precision and high efficiency.

Description

technical field [0001] The invention relates to a device and method for performing dielectric characterization of micro-nano biological particles by using an optical mode virtual electrode array and a physical entity electrode array integrated on a single chip, and relates to the field of microfluidic chips, especially microfluidic biomedicine detection field. Background technique [0002] Compared with traditional large-scale medical testing instruments, microfluidic biomedical chips are favored due to the characteristics and advantages of fewer samples required, low energy consumption, small size, flexible combination of various unit technologies on tiny platforms, and large-scale integration. It is considered to be an ideal platform for the implementation of the "home-based" point-of-care detection concept, which provides the possibility for rapid, accurate, and low-cost detection and early diagnosis of major diseases. Microfluidic biomedical chip, also known as Micro-To...

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Problems solved by technology

[0008] Technical problem: The purpose of the present invention is to provide a multi-mode integrated dielectric characterization device and operation method of micro-nano biological particles, which integrates the optical mode virtual electrode and the physical entity electrode array on a single chip to realize two kinds of electrodes The advantages of each other are complementary, and the dielectric spectrum of the particles under the action of lifting dielectrophoresis, traveling wave dielectrophoresis and electrorotation dielectrophoresis is completed on the chip, so as to realize the dielectric characterization of high-precision and low-cost particles, so as to solve the current problem of obtaining biological particles The defects of limited information on the dielectric properties of the micro-nano biological particles, the high cost of integrated pre-treatment microfluidic chips, and the difficulty in identifying and characterizing micro-nano biological particles with similar dielectric properties

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