Novel uses of Calotropis gigantea and extract thereof in preparing anti-tumor medicament

An anti-tumor drug, a technology of horn melon, which is applied in the field of new uses of horn melon and its extract in the preparation of anti-tumor drugs, can solve problems such as no literature reports and patent disclosures, and achieves less side effects, convenient treatment, controllable The effect of cancer cell proliferation

Inactive Publication Date: 2009-01-28
INST OF TROPICAL BIOSCI & BIOTECH CHINESE ACADEMY OF TROPICAL AGRI SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The new application of the horned melon and its extracts in the preparation of antitumor drugs...

Method used

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  • Novel uses of Calotropis gigantea and extract thereof in preparing anti-tumor medicament
  • Novel uses of Calotropis gigantea and extract thereof in preparing anti-tumor medicament
  • Novel uses of Calotropis gigantea and extract thereof in preparing anti-tumor medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Take 2.0 kg of dried horn melon, extract with 10 times the amount of 95% ethanol for 3 times (5, 3, 3 days), recover ethanol under reduced pressure, concentrate and dry to obtain extract powder, add appropriate amount of starch to the extract powder, mix well , granulation, drying, granulation, and filling into capsules to make 1000 capsules.

Embodiment 2

[0039]Take 10.0 kg of dried horn melon, percolate with 9 times the amount of 90% ethanol, concentrate the percolation liquid under reduced pressure until it has no alcohol taste to obtain a concentrated liquid, disperse the concentrated liquid in water to form a suspension, and extract it with petroleum ether to obtain a petroleum ether immersion liquid. Paste A, the remaining aqueous solution was filtered and then subjected to macroporous adsorption resin (D-101) column chromatography, eluted with water and methanol successively, and the methanol eluate was collected, concentrated to obtain methanol extract B, and the extract B was dried That is the horn melon extract B. Take 100g of horn melon extract B, add appropriate amount of auxiliary materials such as starch, mix evenly, granulate, dry, and press into 1000 tablets.

Embodiment 3

[0041] Take 5.0 kg of dried horn melon, percolate with 8 times the amount of 80% ethanol, concentrate the percolation liquid under reduced pressure until it has no alcohol taste to obtain a concentrated liquid, disperse the concentrated liquid in water to form a suspension, and extract it with petroleum ether to obtain a petroleum ether immersion liquid. paste, and the remaining aqueous solution is filtered and subjected to macroporous adsorption resin (D-101) column chromatography, eluted with water and methanol successively, and the methanol eluate is collected, concentrated to obtain methanol extract, and the methanol extract is dried to obtain Crow's horn melon extract B; take 25g of Crow's horn melon extract B, add appropriate amount of water for injection to dissolve, adjust the pH value, filter, potting, and sterilize according to the conventional water injection process to make 1000ml; or add an appropriate amount of additives such as Mannitol, dissolved and stirred eve...

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Abstract

The invention discloses a novel application of mudar and the extract thereof in the preparation of antitumor drugs, belonging to the field of Chinese medicines and natural medicines. Mudar is extracted by ethanol and then by petroleum ether, after being filtered, the left water liquid is put on macroporous absorption resin (D101) column chromatograph, water and methanol are sucessively used for eluting, and methanol eluent is collected and concentrated so as to obtain the methanol part; proved by tests, the methanol part obtained by extracting has the function of resisting tumor cells.

Description

technical field [0001] The invention relates to a new medical application of a medicinal plant, in particular to a new application of the horn melon and its extract in the preparation of antitumor drugs, and belongs to the fields of traditional Chinese medicine and natural medicine. Background technique [0002] Calotropis gigantea (L.) Dryand ex Ait.f.] is a plant of the genus Calotropis in the family Asclepiadaceae. Alias: Five Dogs Recumbent Flower, Sheep Dipping Tree, Broken Heart Grass. There are 6 species in the genus Ceratia in the world, which are distributed in Southeast Asia. There are two kinds of oxhorn melon and white flower oxhorn melon in China, which are distributed in Hainan, Yunnan, Guangdong and Guangxi, and grow on low-altitude sunny hillsides, wilderness and seaside. The roots, stems, leaves, fruit and white juice of croissant melon are highly poisonous and highly irritating. Eating a small amount can cause vomiting and diarrhea. Eating a large amount ...

Claims

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Application Information

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IPC IPC(8): A61K36/27A61K9/20A61K9/48A61K9/16A61K9/10A61K9/19A61K9/08A61P35/00
Inventor 戴好富王祝年王茂媛梅文莉吴娇曾艳波
Owner INST OF TROPICAL BIOSCI & BIOTECH CHINESE ACADEMY OF TROPICAL AGRI SCI
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