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Medicine for treating osteoarthritis

An osteoarthritis and drug technology, applied in the field of medicine, to achieve the effect of reducing the dosage, strong analgesic effect and relieving symptoms

Inactive Publication Date: 2009-02-04
NAT INST OF PHARMA R & D CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research on the compound preparation of glucosamine and dexibuprofen has not been reported at home and abroad

Method used

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  • Medicine for treating osteoarthritis
  • Medicine for treating osteoarthritis
  • Medicine for treating osteoarthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0024]The main purpose of the present invention is to make the compound preparation of ibuprofen and glucosamine hydrochloride. For this reason, the present invention determines the prescription ratio with reference to the clinical use doses of dextrobuprofen and glucosamine hydrochloride, and completes the preliminary prescription screening; Determine the final prescription ratio and prescription dosage; conduct toxicity experiments on the determined compound to provide a basis for its further application.

[0025] Describe ibuprofen and dexibuprofen and glucosamine (hereinafter referred to as PS) compound efficacy and toxicity comparison test in detail below.

[0026] Analgesic test method: Select ICR mice, 18-22 g, half male and half male, and divide them into random groups with 10 mice in each group. Dosing according to the grouping situation, intragastric administration of 10ml / kg, continuous administration for 7 days, once a day, 1 hour after the last administration, in...

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PUM

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Abstract

The invention discloses a medicine which cures osteoarthritis and is a compound which is formed by combining (S)-ibuprofen and dextrosamine or the medicine salt thereof according to 1:3 of mass ratio. The (S)-ibuprofen and the dextrosamine are prepared into compound preparation. The characteristics of rapid drug effects and strong abirritation of the (S)-ibuprofen can be used for rapidly relieving symptoms on the one hand; on the other hand, the dextrosamine can defer cartilage degeneration process, repairs cartilage pathological changes, and prevents, even reverses the disease process. Meanwhile, the (S)-ibuprofen and the dextrosamine are prepared into the compound preparation, which can reduce the dose of single medicine and further reduce the toxic side effects. The compound preparation prepared by the (S)-ibuprofen and the dextrosamine of the invention becomes a new medicine which can cure the osteoarthritis.

Description

Technical field: [0001] The invention relates to the field of medicine, in particular to a new drug for treating osteoarthritis. Background technique [0002] 1. The incidence of osteoarthritis [0003] Osteoarthritis (OA), also known as osteoarthritis, degenerative joint disease, senile arthritis, proliferative arthritis, hypertrophic arthritis, is divided into primary arthritis and secondary arthritis. Osteoarthritis is characterized by pain, inflammation, stiffness, swelling, deformity, and dysfunction in the joints of the hands, wrists, ankles, knees, hips, shoulders, and spine. The articular cartilage of the human body inevitably degenerates and wears out with age. The degeneration of cartilage begins in the late 20s. Most people over the age of 50 can show the performance of osteoarthritis on X-rays. 65 Almost all the elderly over the age of 10 suffer from obvious osteoarthritis, so osteoarthritis is a common and frequently-occurring disease in middle-aged and elderl...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61K31/7008A61P19/02A61P29/00
Inventor 孙从新郑礼郑少辉王妮蒋晖陈牛艳
Owner NAT INST OF PHARMA R & D CO LTD
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