Purification method of polyvinyl alcohol resin

A technology of polyvinyl alcohol resin and ethanol, which is applied in the field of purification of polyvinyl alcohol resin as a pharmaceutical excipient, and can solve the problems of polyvinyl alcohol resin color and performance changes, agglomeration, consumption of large steam and dilution gas, etc.

Active Publication Date: 2009-02-04
TIANJIN BOKELIN MEDICINE PACKAGING TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method consumes a large amount of steam and dilution gas, and additional drying treatment is required to remove moisture; the temperature is between 80 and 115°C, which may cause changes in the color and properties of polyvinyl alcohol resin
Moreover, it is only suitable for polyvinyl alcohol resins with a degree of alcoholysis of 90-99%, and for polyvinyl alcohol resins with a low degree of alcoholysis, it may cause melting and agglomeration.
At the same time, this method cannot handle inorganic salts

Method used

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  • Purification method of polyvinyl alcohol resin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Stir the mixed solvent of ethanol and water, wherein the mass percentage of ethanol is 60%, slowly add polyvinyl alcohol resin, stir for 2.5 hours, make the polyvinyl alcohol resin fully swell, continue to add ethanol to make the final concentration of ethanol in the mixed solvent The mass percentage is 75%, continue to stir to precipitate the polyvinyl alcohol resin, vacuum filter, and separate the solid material from the solvent; the separated polyvinyl alcohol resin is vacuum-dried with a vacuum degree of minus 0.15Mpa. The dried material is ground and the particle size is controlled within 200-300um. The organic solvent and inorganic salt residue detection results of the polyvinyl alcohol resin prepared by the method are shown in Table 3 below.

[0030] Table 3 The organic solvent and inorganic salt residue detection data of Example 1

[0031] Industrial Grade Polyvinyl Alcohol Resin

[0032] ethanol

[0033] As can be seen from the table, imp...

Embodiment 2

[0035] Stir the mixed solvent of ethanol and water, wherein the mass percentage of ethanol is 65%, slowly add polyvinyl alcohol resin, stir for 2.5 hours, make the polyvinyl alcohol resin fully swell, continue to add ethanol to make the final concentration of ethanol in the mixed solvent The mass percentage is 80%, continue to stir to precipitate the polyvinyl alcohol resin, and vacuum filter to separate the solid material from the solvent; the separated polyvinyl alcohol resin is vacuum-dried with a vacuum degree of minus 0.15Mpa. The dried material is ground to control the particle size within 200-300um. The organic solvent and inorganic salt residue detection results of the polyvinyl alcohol resin prepared by the method are shown in Table 4 below.

[0036]Table 4 The organic solvent and inorganic salt residue detection data of Example 2

[0037] Industrial Grade Polyvinyl Alcohol Resin

Embodiment 3

[0039] Stir the mixed solvent of ethanol and water, wherein the mass percentage of ethanol is 75%, slowly add polyvinyl alcohol resin, stir for 2.5 hours, make the polyvinyl alcohol resin fully swell, continue to add ethanol to make the final concentration of ethanol in the mixed solvent The mass percent content is 80%, continue stirring to vacuum-dry the isolated polyvinyl alcohol resin, the polyvinyl alcohol resin is precipitated, and vacuum suction is used to separate the polyvinyl alcohol resin from the solvent, and part of the inorganic salt is taken away in the solvent; separation The obtained polyvinyl alcohol resin is vacuum-dried, and the vacuum degree is negative 0.12Mpa. The dried material is ground to control the particle size within 200-300um. The detection results of the organic solvent and inorganic salt residues of the polyvinyl alcohol resin prepared by the above method are shown in Table 5 below.

[0040] Table 5 The organic solvent and inorganic salt residu...

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Abstract

The invention provides a method for purifying polyvinyl alcohol resins. The method comprises the steps as follows: polyvinyl alcohol resins are added to the mixed solvent of ethanol and water and are beaten; ethanol is added so that the polyvinyl alcohol resins are separated out; the polyvinyl alcohol resins separated out are dried. The remaining content in the polyvinyl alcohol resins acquired by using the method meets the requirement of medicinal auxiliary materials.

Description

technical field [0001] The invention relates to the field of chemical pharmacy, in particular to a method for purifying polyvinyl alcohol resin as a medical auxiliary material. Background technique [0002] Polyvinyl alcohol (PVA) resin is a commonly used auxiliary material in medicine. It is characterized in that it is soluble in water, easy to form a film, and has excellent mechanical properties; it has good adhesion to hydrophilic cellulose; Low toxicity, non-irritating. At present, it is used in pharmaceutical preparations to make capsule materials for microcapsules, film-forming materials for film and film-coating agents, etc., and the application effect is good. With the research of new preparations, polyvinyl alcohol resin is more used as the skeleton material of tablets to prepare sustained-release and controlled-release drugs, or to achieve sustained-release effects by preparing drug-loaded microspheres and osmotic pumps. Therefore, the application of polyvinyl al...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F6/00C08F116/06A61K47/32
Inventor 赵永建邵广川王磊
Owner TIANJIN BOKELIN MEDICINE PACKAGING TECH
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