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Saccharification hemoglobin immune sensor based on field effect tube

A technology of glycosylated hemoglobin and field effect tube, which is applied in the field of immunosensors and can solve problems such as the lack of small portable analyzers

Active Publication Date: 2012-01-04
INST OF ELECTRONICS CHINESE ACAD OF SCI +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is no hemoglobin analyzer in China, let alone a small portable analyzer.

Method used

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  • Saccharification hemoglobin immune sensor based on field effect tube
  • Saccharification hemoglobin immune sensor based on field effect tube
  • Saccharification hemoglobin immune sensor based on field effect tube

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Experimental program
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Effect test

Embodiment 1

[0024] The preparation and use method of the glycosylated hemoglobin sensor based on the field effect tube are as follows:

[0025] 1) Prepare the basic sensor chip

[0026] On the silicon wafer, two pairs of differential field effect transistors and corresponding differential amplifier circuits are prepared by tape-out using standard CMOS technology, and the basic sensor chip is packaged in a standardized manner. Chip pins are: FET operating voltage V dd , ground GND, gates of two pairs of differential field effect transistors (G 1 , G 1r and G 2 , G 2r ), the differential amplified output voltage signal V of two pairs of differential FETs o1 and V o2 . where V o1 and V o2 is the voltage signal related to the concentration of hemoglobin and glycosylated hemoglobin.

[0027] 2) Preparation of disposable immunoassay test strips

[0028] Based on a PET plastic plate, a "mountain"-shaped platinum reference electrode (electrode line width 0.5mm) and a circular sensitive...

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Abstract

The present invention relates to a glycosylated hemoglobin sensor based on the field effect tube; wherein, the sensor comprises a basic sensing chip and a disposable immunoassay test strip; the sensing element of the basic sensing chip adopts the field effect tube which is prepared with the standard CMOS technological stream sheet and integrated with a readout circuit; the basic sensing chip integrates two pairs of differential field effect tubes and corresponding differential readout circuits, which are respectively used for detecting the concentration of the glycosylated hemoglobin and the hemoglobin; the disposable immunoassay test strip is prepared on an insulating material, and comprises two pairs of grid electrodes made of gold and a reference electrode made of platinum; the two pairs of grid electrodes are respectively used for detecting the hemoglobin and the glycosylated hemoglobin; the reaction zone of the disposable immunoassay test strip is limited by an insulating layer, and is exposed out of the sensitive surface of the grid electrodes and the effective part of the reference electrode; and after the disposable immunoassay test strip is connected with the tester, the two pairs of grid electrodes are respectively connected with the grid zones of the two pairs of differential field effect tubes.

Description

technical field [0001] The invention relates to an immune sensor for detecting glycated hemoglobin, in particular to a field effect tube-based immune sensor for glycated hemoglobin. Background technique [0002] Diabetes is one of the high incidences in my country at present. Usually fasting blood glucose or postprandial blood glucose monitoring is used to monitor the condition of diabetes and guide treatment. The overall picture of the condition for a period of time has brought certain difficulties to the reasonable formulation of treatment plans. The ratio of glycosylated hemoglobin (the ratio of glycosylated hemoglobin to all hemoglobin) can reflect the average blood sugar level of 1 to 2 months before the measurement, and can make up for the lack of blood sugar detection, so it is known as the "gold standard" for diabetes monitoring. Domestically, the examination of glycosylated hemoglobin has been gradually listed as an important indicator to understand whether diabetes...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/414G01N33/72
Inventor 边超夏善红张虹李元光杨彬何伟韩泾鸿杨海钢
Owner INST OF ELECTRONICS CHINESE ACAD OF SCI
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