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Malaria assistance bi-hydrogen arteannuin suppository

A dihydroartemisinin and anti-malarial technology, which is applied in the direction of suppository delivery, resistance to vector-borne diseases, anti-infection drugs, etc., can solve the problems of poor treatment effect, inaccurate dosage, large toxic and side effects, etc., and achieve resident Long time, rapid metabolism and excretion, wide distribution effect

Inactive Publication Date: 2009-02-11
HUBEI CHENGTIAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Oral drugs based on dihydroartemisinin have been widely used clinically and put into use in countries where malaria is rampant. However, these drugs are not effective in treating children and coma and vomiting patients, and the dosage is not accurate enough, so that complex High burning rate and high toxic side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0010] 1. The present invention has the following table according to the specific proportion of the weight:

[0011]

name weight

(gram)

Example 1

Example 2

Example 3 Dihydroartemisinin 10 20 60 polyhydrocarbon stearate

Oxy(40) ester

970 960 1704 Polysorbate 80 20 20 36

[0012] The suppository of three different specifications will be formulated by embodiment 1-3 in the above list and made into 1000.

[0013] 2. The implementation process of the specific preparation process of the present invention is as follows:

[0014] (1) Ingredients: Grind dihydroartemisinin into fine powder and pass through a No. 6 sieve. Take 10g of dihydroartemisinin and 8020g of polysorbate, put them in an evaporating dish, grind them to make them fully mixed, then add polyoxyl (40) stearate 970, heat and melt on a water bath at 55-60°C and stir evenly .

[0015] (2) Injection molding: lubricate a clean and dry 10mg (No. 1 p...

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PUM

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Abstract

The invention aims at providing an anti-malarial dihydroartemisinin suppository, which is a rectum or anus dosage regimen, and has the advantages of low recurrence rate, low toxicity, safety, short treatment period, quick results, low cost and speeding up healing process after being used by malaria-patients, thus removing the diseases. The anti-malarial dihydroartemisinin suppository is prepared by adding dihydroartemisinin with suppository base, and the content of the dihydroartemisinin in each grain of the suppository is 10-100mg.

Description

technical field [0001] The invention relates to an antimalarial drug, in particular to an antimalarial dihydroartemisinin suppository and the technical field of production thereof. Background technique [0002] According to statistics, about 300 million people are infected with malaria every year, most of them in Africa, and 1 million of them die, mostly children. Dr Attaran, an associate research fellow at the Royal Institute of International Affairs in London, said children who did not die were often left with physical or mental disabilities. Artemisinin is extracted from Artemisia annua, a traditional Chinese medicine with a history of two thousand years. Studies have proved that the drug has 97% efficacy in treating malaria. Dihydroartemisinin is a derivative of Artemisia annua, which is characterized by high efficiency and quick-acting , Short-acting antimalarials. Oral drugs based on dihydroartemisinin have been widely used clinically and put into use in countries wh...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/02A61K31/357A61P33/06
CPCY02A50/30
Inventor 付保华黄祖元罗光明
Owner HUBEI CHENGTIAN PHARMA
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