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Uses of B vitamins nicotinic amide in regulating body weight, blood sugar and insulin sensibility

A technology of B vitamins and vitamins, applied in the field of biotechnology and medicine, can solve the problems of vomiting, dehydration, accumulation, etc.

Inactive Publication Date: 2009-02-25
SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Current studies have found that glucagon receptor antagonists are mainly vanadium compounds, but these drugs tend to accumulate in bones, kidneys and liver, and cause adverse reactions such as vomiting and dehydration

Method used

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  • Uses of B vitamins nicotinic amide in regulating body weight, blood sugar and insulin sensibility
  • Uses of B vitamins nicotinic amide in regulating body weight, blood sugar and insulin sensibility

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0112] Embodiment 1. Effect of nicotinamide on body weight, body fat and fasting blood sugar of mice fed with low-fat content feed

[0113] Purpose

[0114] In order to test the effect of nicotinamide (NAM) on the body weight, body fat and fasting blood glucose of mice fed with low-fat content feed, in the experiment, low-fat content feed was used to feed C57BL / 6J mice, and nicotinamide was used to intervene the mice by feeding . After 8 weeks of feeding, compare the appearance, body weight, body fat physiological and biochemical indicators between the control group and the experimental group to determine the effect of nicotinamide.

[0115] experimental animals

[0116] Male C57BL / 6J mice were purchased from the Shanghai Experimental Animal Center of the Chinese Academy of Sciences (Slack Experimental Animal Co., Ltd.)

[0117] feed formula

[0118] Feed with low fat content: fat 4.3gm% (10kcal%)

[0119] intervention medication

[0120] Niacinamide: molecular for...

Embodiment 2

[0128] Example 2. Effects of nicotinamide on body weight, body fat and glucose tolerance of mice fed with high-fat diet

[0129] Purpose

[0130] In order to examine the effect of nicotinamide (NAM) on the body weight, body fat and insulin resistance of mice fed with high-fat diet, in the experiment, high-fat diet was used to feed C57BL / 6J mice, and the mice were fed with nicotinamide by way of feeding. intervene. After 8 weeks of feeding, compare the appearance, body weight, body fat and glucose tolerance and other indicators between the control group and the experimental group to determine the effect of nicotinamide.

[0131] experimental animals

[0132] Male C57BL / 6J mice were purchased from Shanghai Experimental Animal Center of Chinese Academy of Sciences (Slack Experimental Animal Co., Ltd.).

[0133] feed formula

[0134] High fat content feed: fat 35gm% (60kcal%)

[0135] intervention medication

[0136] Niacinamide: molecular formula C 6 h 6 N 2 O, p...

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PUM

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Abstract

The invention provides the application of a B vitamin, a physiologically or pharmaceutically acceptable salt of the B vitamin, a hydrate of the B vitamin or a mixture of the B vitamin, the salt and the hydrate in the preparation of a composition for controlling body weight and blood sugar and / or moderating the insulin resistance. The invention also provides a method for losing weight by applying the B vitamin or a composition thereof, and an application of a compound B vitamin or a composition containing B vitamin and having the functions of preventing, controlling or curing diabetes and diseases or symptoms regarding obesity. The composition has high safety, is liable to be accepted by the market, and has the advantages of high solubility, easy absorption and good stability.

Description

technical field [0001] The invention relates to the fields of biotechnology and medicine, in particular to the use of B vitamins in preventing, controlling or treating obesity, insulin resistance and diabetes. Background technique [0002] Obesity is a chronic disease in which body fat accumulates excessively and threatens health. It is due to the increase in the number of fat cells in the body or the volume of obesity, which makes the body weight exceed the standard body weight by more than 20% or the body mass index> 25kg / m 2 pathological state. In 1997, the World Health Organization (WHO) clearly declared obesity a disease. [0003] Obesity, as a systemic endocrine and metabolic disease, not only affects body posture and activities, but also is associated with hyperlipidemia, atherosclerosis, coronary heart disease, diabetes, cancer, gout, fatty liver, endocrine disorders, alveolar hypoventilation syndrome, Cholecystitis, etc. are closely related, and the resistance ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/455A61K31/51A61K31/714A61K31/4415A61K31/525A61K31/519A61P3/10A61P3/06
Inventor 翟琦巍张芳孙诚
Owner SHANGHAI INST OF BIOLOGICAL SCI CHINESE ACAD OF SCI