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Pharmaceutical composition for easing pruritus

A composition and technology for pruritus, applied in the directions of drug combination, drug delivery, active ingredients of heterocyclic compounds, etc., can solve problems such as patients who are not suitable for chronic pruritus and have side effects

Active Publication Date: 2009-03-11
SUNNY PHARMTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many patients demonstrate persistent pruritus despite treatment with antihistamines, 5-HT receptor antagonists, and / or immunosuppressants, because these agents are only suitable for short-term treatment and have side effects, and Not suitable for patients with chronic itching

Method used

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  • Pharmaceutical composition for easing pruritus
  • Pharmaceutical composition for easing pruritus
  • Pharmaceutical composition for easing pruritus

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0024] 1. Preparation of various types of oily ointments, creams and gels

[0025] A. Preparation of phenylbutyrate oily ointment

[0026] Mix 65 grams of white petrolatum (Riedel-de Haen), 15 grams of cetyl alcohol (Riedel-de Haen), 260 grams of soft paraffin (Merck), 155 grams of liquid paraffin (Merck), and 5 grams of 4-phenylbutyrate (Merck) were mixed in a beaker and heated to 70°C to form a paste. The paste was stirred at 400 rpm for 1 hour and cooled to room temperature.

[0027] B. Preparation of Phenylbutyrate Emulsion

[0028] First ingredient: 70 grams 20 grams 10 grams Coster 15 grams Myriyol 15g Coster and 15 grams of GMS (both available from local suppliers) were mixed in a beaker and heated to 70°C.

[0029] Second component: 5.739 grams sodium 4-phenylbutyrate (Triple Crown America, Inc.), 0.125 grams methylparaben (Merck), 0.075 grams propylparaben (Merck ), and 149.061 grams of deionized water were mixed in a beaker and heated to 70°C.

[003...

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PUM

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Abstract

The invention relates to a pharmaceutical composite which inhibits and / or relieves pruritus caused by dermatosis, mucosa disease or systemic disease or lesion, and is made from derivatives, salt or solvate of phenyl butyric acid and short chain fatty acid with effective dose and a carrier which is acceptable pharmaceutically.

Description

technical field [0001] The present invention relates to a pharmaceutical composition for inhibiting and / or alleviating pruritus, and in particular to a pharmaceutical composition for inhibiting and / or alleviating pruritus by using phenylbutyric acid derivatives or short-chain fatty acid derivatives. Background technique [0002] Pruritus produces symptoms such as discomfort and itching, sometimes causing redness, swelling and pain on the patient's skin. Pruritus is considered to be a broad range of physical, chemical and / or biological stimuli that can be internal or external. Pruritus is assigned to a specific skin condition, eg, drug allergy, insect bites, environmental allergens, or systemic disease, eg, thyrotoxicosis, diabetes, uremia, iron deficiency anemia, delusional parasitosis , Polycythemia vera, cholestasis, Hodgkin's disease. Although pruritus is more common in the skin, it can also occur in non-cutaneous sites such as mucous membranes. Therefore, the cause of...

Claims

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Application Information

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IPC IPC(8): A61K31/192A61K31/19A61K31/16A61K31/216A61K31/44A61K45/06A61K9/00A61K9/06A61K9/107A61K9/127A61P17/04A61P17/00
Inventor 钟邑林贝南谋张葳葳
Owner SUNNY PHARMTECH
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