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Chitosan-hydroxyapatite composite spheroidal particle, producing method and apparatus thereof

A technology of hydroxyapatite and nano-hydroxyapatite, which can be used in dental preparations, pharmaceutical formulations, dental prostheses, etc., can solve the problems of large diameter distribution of microspheres, unfavorable growth of new tissue, and high filling density.

Inactive Publication Date: 2013-08-07
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The microspheres prepared by these methods have a large diameter distribution range and a high packing density. When applied to tissue filling, the pores between the particles are too small, which is not conducive to the growth of new tissues.

Method used

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  • Chitosan-hydroxyapatite composite spheroidal particle, producing method and apparatus thereof
  • Chitosan-hydroxyapatite composite spheroidal particle, producing method and apparatus thereof
  • Chitosan-hydroxyapatite composite spheroidal particle, producing method and apparatus thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) take by weighing the chitosan that accounts for solution gross mass 5%, be dissolved in the acetic acid solution that mass concentration is 1%, be mixed with chitosan acetic acid solution, then be 2 by the mass ratio of hydroxyapatite and chitosan : 1 takes by weighing nano-hydroxyapatite;

[0029] (2) adding nano-hydroxyapatite in chitosan-acetic acid solution, fully stirring to obtain chitosan-hydroxyapatite suspension;

[0030] (3) figure 1 As shown, the prepared chitosan-hydroxyapatite suspension is added to the storage tank 4 from the feed port 1, and the pressure in the storage tank 4 is controlled by the pressure gauge 2 and the pressure control valve 3 to be 0.08MPa to ensure The chitosan-hydroxyapatite suspension flows out evenly at a rate of 10 drops / min from the catheter 6 with a pipe diameter of φ0.5mm. The flow rate can be controlled by the flow control valve 5, and the solution is dripped into the heat preservation container 8 Condensate in the conde...

Embodiment 2

[0033] (1) taking by weighing chitosan accounting for solution gross mass 15% is dissolved in the acetic acid solution that mass concentration is 3% and is mixed with chitosan-acetic acid solution, then is 6 by the mass ratio of hydroxyapatite and chitosan: 1 Weighing nano-hydroxyapatite;

[0034] (2) adding nano-hydroxyapatite to chitosan-acetic acid solution, fully stirring to obtain chitosan-hydroxyapatite suspension;

[0035] (3) The prepared suspension is added to the storage tank 4 from the feeding port 1, and the pressure in the storage tank 4 is controlled by the pressure gauge 2 and the pressure control valve 3 to be 0.5MPa to ensure that the chitosan-hydroxyapatite is suspended The liquid flows out uniformly at a rate of 60 drops / min from the catheter 6 with a pipe diameter of φ3mm, and the flow rate can be controlled by the flow control valve 5. The solution drips into the condensate 7 in the heat preservation container 8 to condense, and the temperature of the cond...

Embodiment 3

[0038] (1) Weigh chitosan accounting for 25% of the total mass of the solution and dissolve it in an acetic acid solution with a mass concentration of 5% to make a chitosan-acetic acid solution. The mass ratio of hydroxyapatite to chitosan is 2:5. Take nano-hydroxyapatite;

[0039](2) adding the nano-hydroxyapatite to the chitosan-acetic acid solution, fully stirring to obtain a suspension;

[0040] (3) The prepared suspension is added to the storage tank 4 from the feeding port 1, and the pressure in the storage tank 4 is controlled by the pressure gauge 2 and the pressure control valve 3 to be 1.08MPa to ensure that the chitosan-hydroxyapatite is suspended The liquid flows out uniformly at a rate of 40 drops / min from the catheter 6 with a pipe diameter of φ1.5mm, and the flow rate can be controlled by the flow control valve 5. The solution drops into the condensate 7 in the heat preservation container 8 to condense, and the condensate The temperature is -15°C, and the conde...

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Abstract

The invention relates to a chitosan-hydroxyapatite composite spherical particle, and a method and a device for preparing the same. The method comprises the following steps: preparing a chitosan acetic acid solution at first, and then adding nanometer hydroxyapatite into the chitosan acetic acid solution to prepare a suspension liquid, wherein the mass ratio of the hydroxyapatite to the chitosan is (6-1) to (1-5). The prepared suspension liquid is added into a material storage tank from a feed opening, is forced to flow out of a liquid guiding tube evenly through controlling the pressure in the material storage tank, and is dripped into a condensate in a thermal insulation container to be condensed so as to form spherical particles. The condensed spherical particles are treated by freeze-drying at first, then are crosslinked by 2.5 percent of glutaraldehyde solution, and finally are washed by anhydrous ethanol to obtain the chitosan-hydroxyapatite composite spherical porous particle material. The spherical particle material has homogeneous particle diameter distribution, contains a large number of micropores communicated with one another therein, has higher specific surface area, and can be applied to tissue repair and medicament slow release.

Description

1. Technical field [0001] The invention belongs to a preparation technology of spherical granular materials applied in the field of biomedicine, and in particular relates to a chitosan-hydroxyapatite composite spherical particle and a preparation method and device thereof. 2. Background technology [0002] Existing technology: Chitin widely exists in the shells of arthropods such as shrimps, crabs and insects, and in the cell walls of lower plants such as bacteria and algae. It is one of the most abundant biopolymers in nature and is an extremely rich natural compound. recycled resources. Chitosan is the deacetylation product of chitin. Chitosan is non-toxic, biocompatible and biodegradable. In recent years, it has been used as a natural medical polymer material in absorbable surgical sutures, hemostatic materials, wound dressing materials and Research on artificial skin and other aspects is very eye-catching. At the same time, chitosan is also an excellent hard tissue rep...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/20A61L27/12A61L27/56A61K6/097A61K6/033A61K6/838A61K6/898
Inventor 董寅生李姝盛晓波储成林郭超林萍华浦跃朴
Owner SOUTHEAST UNIV