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Methods of treating or preventing inflammation and hypersensitivity reactions using redox potential aqueous solutions

An aqueous solution, potential technology, applied in the direction of peroxide active ingredients, anti-inflammatory agents, resistance to vector-borne diseases, etc., can solve problems such as toxicity and allergic reactions

Active Publication Date: 2015-09-23
宝利宠物用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, commonly used anti-inflammatory therapies have several drawbacks, such as systemic toxicity, allergic reactions, insulin resistance, hypertension, cardiotoxicity, nephrotoxicity, various coagulopathy, and gastric erosion

Method used

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  • Methods of treating or preventing inflammation and hypersensitivity reactions using redox potential aqueous solutions
  • Methods of treating or preventing inflammation and hypersensitivity reactions using redox potential aqueous solutions
  • Methods of treating or preventing inflammation and hypersensitivity reactions using redox potential aqueous solutions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0165] These examples demonstrate the unique characteristics of the ORP water solution used in the present invention. Samples of the ORP water solutions in Examples 1-3 were analyzed according to the methods described herein to determine the physical characteristics and levels of ions and other chemical species present in each sample. The results obtained for chlorine dioxide, ozone and hydrogen peroxide are based on standard tests used to determine these species, but different species can be represented and positive test results can also be produced. Furthermore, it has been reported that chlorine dioxide, ozone and hydrogen peroxide react with hypochlorite, leading to its consumption and other compounds such as HCl and O 2 )produce. The pH, oxidation-reduction potential (ORP) and ion species present for each sample of the ORP water solution are listed in Table 1.

[0166] Table 1. Physical properties and ionic species present in ORP water solution samples

[0167] ...

Embodiment 4-10

[0170] These examples demonstrate the addition of varying amounts of bleach to the ORP water solution of the present invention. In particular, these examples demonstrate the antimicrobial activity and fabric bleaching capabilities of the compositions.

[0171] Prepare 10% using distilled water bleach solution. The following solutions were then prepared using the 10% bleach solution: 80% ORP water solution / 20% bleach (Example 4); 60% ORP water solution / 40% bleach (Example 5); 40% ORP water solution / 60% bleach ( Example 6); 20% ORP water solution / 80% bleach (Example 7); and 0% ORP water solution / 100% bleach (Example 8). Two control solutions were also used for comparison, including 100% ORP water solution / 0% bleach (Example 9) and ORP water solution with 0.01% Tween 20 disinfectant (Example 10). The physical properties of these samples, especially pH, oxidation-reduction potential (ORP), total chlorine (Cl-) content and hypochlorous acid (HClO-) content were determined and c...

Embodiment 11

[0184] The purpose of this study was to evaluate the safety of Microcyn, a typical ORP water solution, when administered as drops into the nasal cavity of rabbits. The 33 rabbits were randomly divided into two groups, Group I and Group II. Group I (18 animals) was used as a control group and Group II (15 animals) was given the test article. On day -1 or day 0, body weights were recorded and blood samples were collected for analysis of selected parameters. On day 0, animals in group I were given 500 μL of sterile saline and animals in group n (annuals) were given 500 μL of test article (at 50% concentration). The control and test articles were administered as drops into the right nostril twice daily. Animals were dosed in the same manner on days 1-6. Animals were observed daily for pharmacological and / or toxicological effects with dedicated nasal attention. Body weights were recorded weekly until study termination. On day 7, one-third of the animals in each group were sele...

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Abstract

Methods of using oxidative reduction potential (ORP) water solution that is stable for at least twenty-four hours in dental applications are provided. The ORP water solution can be administered to patients for the routine disinfection of the oral cavity as part of an on-going program of oral hygiene. The ORP water solution can further be used to irrigate and / or disinfect oral tissues and surfaces during dental procedures, oral surgery, or maxillo-facial surgery. Also, the ORP water solution can be administered to treat patients with damage to the oral tissues caused by disease or surgery.

Description

[0001] Cross References to Related Applications [0002] This patent application requests U.S. Provisional Patent Application No. US60 / 760,635 filed January 20, 2006, U.S. Provisional Patent Application No. US60 / 760,567 filed January 20, 2006; U.S. Provisional Patent Application No. 1, 2006 No. US 60 / 760,645; and U.S. Provisional Patent Application No. US 60 / 760,557, filed January 20, 2006, the entire contents of which are incorporated herein by reference in their entirety. Background of the invention [0003] Inflammation is a biological response that can result from a noxious stimulus and it is generally desirable to remove the stimulus or ameliorate its effects. Although generally expected to promote survival, inflammation can lead to damage to the host, especially mammals. Stimuli or injuries that cause inflammation can be caused by endogenous agents (such as self-antigens or irritating humors) or exogenous agents (such as foreign bodies or pathogens). [0004] Inflammat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/40A61P29/00
CPCY02A50/30
Inventor H·阿里米A·古蒂雷斯
Owner 宝利宠物用品有限公司
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