Piperidinyl, indolyl, pirinidyl, morpholinyl and benzimidazolyl urea derivatives as inhibitors of soluble epoxide hydrolase for the treatment of hypertension, inflammations and other diseases

A technology of derivatives, compounds, piperidinyl, indolyl, pyridyl, morpholinyl and benzimidazolyl inhibitors of soluble epoxide hydrolase for the treatment of hypertension, inflammation and other diseases Urea derivatives field
CN101405264AInactive Publication Date: 2009-04-08RGT UNIV OF CALIFORNIA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
RGT UNIV OF CALIFORNIA
Publication Date
2009-04-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

Compounds of the formula (I); wherein R<1> is a member selected from the group consisting of C1-C8alkyl, arylC0-C8alkyl, C3-C12cycloalkyl and heterocyclyl, Y<1> is selected from the group consisting of a bond, C(R<5>)2, NR<5> and O; Y<2> is selected from the group consisting of a bond, NR<5> and O; each R<2>, R<3> and R<5> is independently selected from the group consisting of H, alkyl and COR<6>; A is heterocyclyl, optionally substituted with from 1 to 2 R<7> substituents; L is selected from the group consisting of a direct bond, C1-C12alkylene, C1-C12heteroalkylene, C3-C6cycloalkylene, arylene, heteroarylene, -CO-, -SOin- and -Se-; R<4> is selected from the group consisting of H, C1C8alkyl, C2-C6alkenyl, C2-C6alkynyl, C1,-C8heteroalkyl, arylC0-C8alkyl, C3C,12cycloalkyl and heterocyclyl, are claimed. The compounds are inhibitors of the soluble epoxide hydrolase (sEH) and useful for the treatment of hypertension, inflammation, adult respiratory distress syndrome; diabetic complications; end stage renal disease; Raynaud syndrome and arthritis.
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Description

[0001] Cross References to Related Applications

[0002] This application claims priority to US Provisional Patent Application Serial No. 60 / 782,172, filed March 13, 2006, the contents of which are incorporated herein by reference.

[0003] Claims of Rights to Inventions Resulting from Federally Sponsored Research or Development

[0004] The United States Government has certain rights in this invention under contracts ES02710 and HL078096 awarded by the National Institutes of Health. Background of the invention

[0005] Epoxide hydrolases (EH, EC 3.3.2.3) catalyze the hydrolysis of epoxides or arene oxides to their corresponding diols by adding water (see, Oesch, F. et al., Xenobiotica, 1973, 3, 305-340) . Some EHs play critical roles in the metabolism of various compounds, including hormones, chemotherapeutic drugs, carcinogens, environmental pollutants, mycotoxins, and other harmful foreign compounds.

[0006] Microsomal epoxide hydrolase (mEH) and soluble epoxide hydrola...

Claims

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