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Preparation method of total alkaloid salt of Corydalis and its application as a drug for treating cardiovascular diseases

A technology of total alkaloids and Corydalis, which is applied in cardiovascular system diseases, drug combinations, medical preparations containing active ingredients, etc., can solve low bioavailability, poor effect of cardiovascular diseases, poor water solubility of total alkaloids of Corydalis etc. to achieve the effect of high bioavailability and good water solubility

Inactive Publication Date: 2011-12-07
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Description
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  • Application Information

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Problems solved by technology

[0003] In order to solve the problem of poor water solubility and low bioavailability of total alkaloids of Corydalis, the present invention provides a preparation method and application of total alkaloids of Corydalis

Method used

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  • Preparation method of total alkaloid salt of Corydalis and its application as a drug for treating cardiovascular diseases
  • Preparation method of total alkaloid salt of Corydalis and its application as a drug for treating cardiovascular diseases

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specific Embodiment approach 1

[0009] Embodiment 1: The preparation method of the total alkaloid salt of Corydalis Corydalis in this embodiment is as follows: 1. Pulverize the Corydalis Corydalis medicinal material into a 20-50 mesh coarse powder, extract the Corydal Corydalis Corydalis medicinal material coarse powder with solvent extraction, and then filter the extract ; 2. Pass the extract through a strong-acid cation exchange resin column at a flow rate of 2 to 15ml / min for exchange and adsorption; 3. Clean the strong-acid cation-exchange resin after exchange and adsorption with distilled water until the cleaning solution is colorless, and use a strong-acid cation exchange resin Soak strong-acid cation-exchange resin in ammonia water with 1 / 16-1 / 4 of the weight of the exchange resin for 6-24 hours, then use organic solvent to reflux or Soxhlet-extract the alkalized strong-acid cation-exchange resin, the extraction time is 2 After ~8 hours, filter the extract and reclaim the organic solvent to obtain the ...

specific Embodiment approach 2

[0011] Embodiment 2: The difference between this embodiment and Embodiment 1 is that in step 1, Corydalis Corydalis is crushed into 25-35 mesh coarse powder. Other steps and parameters are the same as those in Embodiment 1.

specific Embodiment approach 3

[0012] Embodiment 3: The difference between this embodiment and Embodiment 1 is that in step 1, Corydalis Corydalis is crushed into 20-mesh coarse powder. Other steps and parameters are the same as those in Embodiment 1.

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Abstract

The preparation method of the total alkaloid salt of Corydalis Corydalis and its application as a medicine for treating cardiovascular diseases. The invention relates to a preparation method of a traditional Chinese medicine alkaloid salt and its application. The invention solves the problem that the total alkaloids of Corydalis Corydalis has poor water solubility and low bioavailability, and thus has poor therapeutic effect on cardiovascular diseases. The preparation method of the total alkaloid salt of Corydalis is as follows: the crude powder of Corydalis is extracted and purified to obtain the total alkaloids of Corydalis, and then the total alkaloids of Corydalis is obtained through salt-forming reaction with acid. The extraction rate of the total alkaloids of Corydalis of the present invention is more than 0.5%, the purity of the total alkaloids of Corydalis obtained is more than 50%, the total alkaloids of Corydalis salt is good in solubility, the solubility is more than 60%, and the bioavailability is high. The active ingredient of disease medicine, used in the treatment of coronary heart disease, angina pectoris, arrhythmia and premature beats.

Description

technical field [0001] The invention relates to the preparation and application of a traditional Chinese medicine alkaloid salt. Background technique [0002] Worldwide, coronary heart disease has become one of the most serious diseases threatening human health, and its morbidity and mortality are on the rise. The average prevalence of coronary heart disease in my country is 6.49%, and it increases with age. Therefore, coronary heart disease is the most common cardiovascular disease among middle-aged and elderly people. Studies have shown that the main active ingredients of Corydalis are total alkaloids, including d-corydalline, d-corydalis monophenolic alkaloids, d1-tetrahydropalmatine, 1-tetrahydrocorydine, and dehydrocorydalis Alkali, 1-coptisine, protopine, 1-tetrahydro-African antihexamine, etc. The total alkaloids of Corydalis can expand coronary blood vessels, improve coronary blood flow, and protect myocardial ischemia and necrosis. In clinical practice, the total...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/66A61P9/06A61P9/10
Inventor 田明孙世晓周忠光来杰
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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