Use of winged euony twigs in preparing anti-IV type allergy medicine
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A technology of allergy and ghost arrow feathers, applied in the field of medicine, can solve the problems of tissue cell damage and harm to the body.
Inactive Publication Date: 2009-05-06
黄德斌 +2
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It can be seen that, on the one hand, it is beneficial to the body due to the protective effect of cellular immunity; on the other hand, it causes damage to tissue cells and is harmful to the body.
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Embodiment 1
[0010] Example 1 Preparation of the total ethanol extract of Erythriflora: take the dried stem bark of Erythria erinaceus, pulverize it with a drug grinder, soak it in 70% ethanol, and extract it 3 times under reflux in a water bath at 60°C, combine the reflux liquid and collect it after filtration. Distilled under reduced pressure in a rotary evaporator, recovered to no alcohol smell, and dried to obtain a tan dry extract.
Embodiment 2
[0011] Example 2 The preparation of the total flavans of Astragalus: Dissolve the ethanol extract in distilled water, extract with equal volume of petroleum ether, ethyl acetate, and n-butanol for 3 times, recover the solvents respectively, and dry in vacuum (80°C) to obtain petroleum Ether extract and ethyl acetate extract, n-butanol extract, extraction residue. The total flavans were identified mainly in the ethyl acetate extract.
Embodiment 3
[0012] Example 3 The effect of Guijianyu extract on delayed paw swelling in mice induced by sheep erythrocytes
[0013] 1. Animals: Clean-grade ICR mice, 20-25g, 2-3 months old, half of each for ♂♀, provided by the Medical Experimental Animal Center of Tongji Medical University. The experiment was started after male and female animals were fed with normal diet separately for 5 days. The room temperature was controlled at 22±2° C. and the humidity was 55±15%.
[0014] 2. Drugs: prednisone acetate, provided by Jiangsu Huaiyin Pharmaceutical Factory; the extract of ghost arrow feather, prepared by Examples 1 and 2.
[0015] 3. Experimental method: 80 clean-grade ICR mice, half male and half male, were randomly divided into 8 groups. Simultaneously and 16 hours after sheep red blood cell challenge, the ethanol extract or total flavans were administered twice, the positive control group was administered prednisone, and the blank control group was administered intragastrically equa...
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Abstract
The invention relates to the medical technique field and discloses an application for preparing IV-type allergic response resistance medicament of an extract of ramulus euonymi which is a celastraceae plant. The animal models (sheep red blood cell causing mice delayed type pedal swelling, olive oil causing mice dermatitis contacta, 5-HT causing rat mastocyte in abdominal cavity releasing histamine, 5-HT inducing guinea pig ileum shrinking) which are broadly used for screening IV-type allergic response resistance in at home and abroad at present, verifies that the extract of the ramulus euonymi can obviously inhibit the mice delayed type pedal swelling caused by sheep red blood cells, the mice dermatitis contacta caused by olive oil, the rat mastocyte in abdominal cavity releasing histamine caused by 5-HT and the guinea pig ileum shrinking caused by 5-HT, thereby proving that the ramulus euonymi has exact effect in resisting IV-type allergic response, and therefore the ramulus euonymi can be used for preparing IV-type allergic response resistance medicament.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to the application of Guijianyu in anti-type IV allergy drugs. Background technique [0002] Type IV allergy, also known as delayed-type allergy, is a local allergic inflammation characterized by mononuclear cell infiltration and cell degeneration and necrosis. It is caused by the combination of sensitized T lymphocytes and corresponding antigens, and neither antibodies nor complement are involved. . This type of reaction occurs slowly, and generally takes 48 to 72 hours. When the sensitized T lymphocytes bind to the corresponding antigen, the target cells are stimulated to change the permeability of the cell membrane, so that K+ in the cells escapes, and Na + Entering the cell, the result is that the osmotic pressure of the cell changes, the cell swells, and finally lyses. However, the sensitized T lymphocytes involved in this reaction are not destroyed and can continue to dest...
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