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Atractylodes rhizome extract soft capsule and preparation method thereof

A kind of Atractylodes atractylodis extract and soft capsule technology, which is applied in capsule delivery, drug combination, pharmaceutical formula, etc. It can solve the problems of uneven dispersion, coagulation of contents, long disintegration time, etc., and achieve high bioavailability and rapid disintegration , good stability

Active Publication Date: 2009-07-08
SHENZHEN NEPTUNUS PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the Atractylodes atractylodes oil soft capsule prepared by the above method, after being placed at 4°C for 3 to 4 days, the contents will solidify, the dispersion will be uneven, and even some solids will precipitate out, which shows that under low temperature conditions, Atractylodes atractylodes oil can be used in salad oil. In the oily environment, the solubility decreases
In addition, the disintegration time of the preparation is longer, indicating that the soft capsule dissolves slowly, which reduces the bioavailability of the drug in the body

Method used

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  • Atractylodes rhizome extract soft capsule and preparation method thereof
  • Atractylodes rhizome extract soft capsule and preparation method thereof
  • Atractylodes rhizome extract soft capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1 Preparation of Atractylodes Atractylodes Extract

[0035] (1) Medicinal materials and processing

[0036] Atractylodes raw medicinal materials: Atractylis lancea dry rhizome. purchased from Luotian, Hubei. Crush and sieve.

[0037] Atractylodes herb medicinal materials: operate according to the method of bran frying in Appendix I of the 1995 edition of "Chinese Pharmacopoeia", let cool, pulverize, and sieve.

[0038] (2) Extraction

[0039] Separately take 4kg of raw Atractylodes atractylodis and processed medicinal material powder and place them in different distillation devices. Refer to the method of Chinese Pharmacopoeia, steam distillation and extraction for 8 hours to separate oil from water and collect volatile oil. Detect gained oily extract (Atractylodis volatile oil), the result is as follows:

[0040] Table 1. Extracts obtained by different extraction methods

[0041]

[0042] The test results of the volatile oil obtained by steam distilla...

Embodiment 2

[0057] Example 2 Acute Toxicity Test of Atractylodes Atractylodes Extract

[0058] (1) Each extract described in Example 1 of the test sample, including

[0059] Sample 1: Steam Distilled Extract of Herba Atractylodis;

[0060] Sample 2: Steam Distilled Extract of Atractylodes Rhizome;

[0061] Sample 3: Atractylodes atractylodis total terpene alcohol extract obtained by steam distillation and rectification.

[0062] (2) Test animals Mice

[0063] (3) Test method and literature method (Edited by Li Yikui et al., Pharmacological Experimental Methodology of Traditional Chinese Medicine, Shanghai Science and Technology Press, Shanghai, 1991; p528~531)

[0064] (4) Test results

[0065] Sample 1: LD50=2.394±0.652g / kg;

[0066] Sample 2: LD50 = 5.743 ± 1.861g / kg;

[0067] Sample 3: LD10 = 12.76 ± 2.846g / kg;

[0068] The experimental results show that after processing Atractylodes atractylodes, the acute toxicity of the obtained steam distillation extract is reduced; after...

Embodiment 3

[0069] Example 3 Effects of Total Terpene Alcohol Extract of Atractylodes Rhizoma Atractylodis on Animal Model of Gastric Ulcer

[0070] 1. The role of acute gastric ulcer

[0071] (1) Each extract described in Example 1 of the test sample, including

[0072] Sample 1: Steam Distilled Extract of Herba Atractylodis;

[0073] Sample 2: Steam Distilled Extract of Atractylodes Rhizome;

[0074] Sample 3: Atractylodes atractylodis total terpene alcohol final product obtained by steam distillation and rectification.

[0075] Sample 4: Majool.

[0076] Sample 5: atractyl alcohol (mauryl alcohol: β-cineole = 5:3).

[0077] Sample 6: the control drug ranitidine.

[0078] (2) Test method:

[0079] A rat model of pylorus-ligated gastric ulcer was used. A total of 70 SD rats, body weight 175.5 ± 12.7. Before the experiment, the rats were fasted for 48 hours in separate cages, and they were allowed to drink water freely during the fasting period.

[0080] During the experiment,...

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PUM

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Abstract

The invention relates to a soft capsule preparation with rhizoma atractylodis extract and a preparation method thereof. The liquid medicine of the preparation contains rhizoma atractylodis extract, dissolvent and supensoid agents, and a soft capsule shell contains colla taurina, glycerin, water and preservatives. Compared with the existing preparation types, the rhizoma atractylodis oil soft capsule has the advantages of stability, safety, short disintegration time, low toxicity, high drug effect and bioavailability and convenient use.

Description

technical field [0001] The invention relates to the technical field of preparations of Chinese patent medicines, in particular to soft capsules of herb extracts and a preparation method thereof. Background technique [0002] Atractylodes atractylodes is the dried rhizome of Atractylodes atractylodes (also known as Atractylodes lancea (Thunb.) DC) and Atractylodes atractylodes (also known as Atractylodes lancea, Atractylodes chinensis Koidz.) of Compositae. Cangzhu was first recorded in "Shen Nong's Materia Medica", and it was listed as the top grade. It is said that it "maintains wind-cold-damp arthralgia, dead muscle spasm, and can be used as decoction for a long time to make light body and prolong life without hunger." [0003] With the development of science and technology, scholars have gradually deepened their research on Cang Zhu. Zhang Qiuhua and others pointed out that Atractylodes atractylodes mainly contains volatile oil and is composed of a series of sesquiterpen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/284A61K9/48A61P1/04
Inventor 肖波梁慧王志国赵金华冯汉林于琳
Owner SHENZHEN NEPTUNUS PHARM CO LTD