Method for extracting chlorogenic acid in honeysuckle
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A technology of honeysuckle and chlorogenic acid, which is applied in the chemical industry, can solve the problems of large loss of chlorogenic acid, time-consuming and energy-consuming filtration, and large amount of sedimentation, so as to reduce the difficulty of filtration, increase the processing capacity, improve product purity and obtain rate effect
Inactive Publication Date: 2009-08-12
ANHUI QIMEN HUANGSHAN YAOGU BIOLOGY SCI & TECH
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Problems solved by technology
At present, the methods for extracting chlorogenic acid from honeysuckle mainly include water extraction, water extraction and alcohol precipitation, and dilute alcohol extraction. Precipitation carries disadvantages such as large loss of chlorogenic acid
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Embodiment 1
[0006] Example 1. Take 200g of crushed honeysuckle and extract dynamically with 1000g of petroleum ether at 30°C±2°C for 6 hours, filter out the solution, and repeat the extraction once with 1000g of fresh petroleum ether. The solutions were combined, and the honeysuckle extract was obtained after recovering the petroleum ether, which was stored separately.
[0007] The honeysuckle after petroleum ether leaching was refluxed with 600g ethyl acetate for 30 minutes, the extract was filtered off, and the extraction was repeated once with 600g ethyl acetate. Combine the extracts and recover the ethyl acetate to obtain a brown-yellow extract, which is mainly chemically characterized as flavonoids, which is stored separately.
[0008] The honeysuckle extracted with ethyl acetate was dynamically extracted with 2000g of water at 60°C for 1 hour, and the filtrate was obtained by filtration; the extraction was repeated once with 2000g of water. Combine the filtrates, concentrate under...
Embodiment 2
[0010] Example 2. Take 300g of crushed honeysuckle, and extract dynamically with 1500g of petroleum ether at 30°C±2°C for 8 hours, filter out the solution, and repeat the extraction once with 1500g of fresh petroleum ether. The solutions were combined, and the honeysuckle extract was obtained after recovering the petroleum ether, which was stored separately.
[0011] The honeysuckle after petroleum ether leaching was refluxed with 900g ethyl acetate for 30 minutes, the extract was filtered off, and the extraction was repeated once with 900g ethyl acetate. Combine the extracts and recover the ethyl acetate to obtain a brown-yellow extract, which is mainly chemically characterized as flavonoids, which is stored separately.
[0012] The honeysuckle extracted with ethyl acetate was dynamically extracted with 3000g of water at 60°C for 1 hour, and the filtrate was obtained by filtration; the extraction was repeated once with 2000g of water. Combine the filtrates, concentrate unde...
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Abstract
The invention relates to a method for extracting chlorogenic acid in honeysuckle, belonging to the technical field of chemical engineering. The invention aims at providing the method for extracting chlorogenic acid in honeysuckle, so as to solve the problem that the existing chlorogenic acid extract is difficult to filter caused by a great amount of precipitation generated in the process of impurity removal and purification, thus improving the purity and yield of the product. Meanwhile, when the chlorogenic acid in the honeysuckle is extracted, a series of products with higher added value can be produced, so that the raw material resource of the honeysuckle can be better utilized. The method comprises the technical key points: the ground honeysuckle is leached in a dynamic state by petroleum ether, and fragrant extract of the honeysuckle in obtained by concentration after the extracting solution is filtered and the petroleum ether is recovered; after the petroleum ether is leached, the honeysuckle is extracted by reflux by using ethyl acetate, and the ethyl acetate is recovered after the extracting solution is filtered, so that honeysuckle general flavone is obtained by concentration; the honeysuckle processed by reflux extraction by using ethyl acetate is added with water for dynamic extraction, and the extracting solution is filtered, decompressed, concentrated, deposited in alcohol, decolored, purified, concentrated and dried, so that the chlorogenic acid in the honeysuckle can be obtained.
Description
Technical field: [0001] The invention relates to a method for extracting chlorogenic acid from honeysuckle, belonging to the technical field of chemical industry. Background technique: [0002] Honeysuckle is the dried flower bud of Lonicera Lonicerae. The main active ingredient is chlorogenic acid, which is easily soluble in water, alcohol, acetone and other solvents, insoluble in petroleum ether, and slightly soluble in ethyl acetate. At present, the methods for extracting chlorogenic acid from honeysuckle mainly include water extraction, water extraction and alcohol precipitation, and dilute alcohol extraction. Precipitation carries disadvantages such as large loss of chlorogenic acid. Invention content: [0003] The purpose of the present invention is to provide a method for extracting chlorogenic acid in honeysuckle, to solve the difficulty in filtering current chlorogenic acid extracts due to the large amount of precipitation in the process of impurity removal and p...
Claims
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