Preparation method of astragalus total-saponin sodium chloride injector
A saponin sodium chloride, injection technology, applied in non-active ingredients medical preparations, medical preparations containing active ingredients, digestive system, etc., can solve the problem of poor stability, low solubility of active ingredients in total astragalus saponins injection problem, to achieve the effect of stable quality, stable liquid, and increased solubility
Active Publication Date: 2010-12-01
山西振东泰盛制药有限公司
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The present invention provides a preparation method of total astragalosides sodium chloride injection in order to solve the problems of low solubility of active ingredients in the total astragalus saponins injection and poor stability during storage in the prior art
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The invention relates to a radix astragali pharmaceutical preparation, in particular to a method for preparing a radix astragali total saponin sodium chloride injection. The method solves the problems existing in the prior art that an effective ingredient of the radix astragali total saponin sodium chloride injection has small solubility, and poor stability during the storage and the like. The method comprises the steps of: adding polyethylene glycol-12-hydroxystearate into water for injection, stirring the mixture to prepare a solution with mass proportion of between 2 and 5 percent; adding total saponins from radix astragali and sodium chloride into the polyethylene glycol-12-hydroxystearate solution, stirring, and dissolving; filtering and decarburizing; and encapsulating and sterilizing. The method for preparing the radix astragali total saponin sodium chloride injection can greatly improve the solubility of the total saponins from radix astragali in water, improve the stability of the total saponins from radix astragali in the water, does not produce a precipitate when placed for a long time at temperature of 60 DEG C, between 18 and 26 DEG C, and between 0 and 4 DEG C under light conditions, and has steady quality as well as convenient and safe clinical use.
Description
The preparation method of total astragalus saponins sodium chloride injection technical field The invention relates to an astragalus medicinal preparation, in particular to a preparation method of total astragalus saponins sodium chloride injection. Background technique Astragalus is a commonly used traditional Chinese medicinal material, which has the effects of nourishing vitality, strengthening the body and eliminating pathogenic factors, nourishing the heart and clearing the meridian, invigorating the spleen and dampness. In modern clinics, it is widely used in viral myocarditis caused by heart-qi deficiency and blood stasis, heart insufficiency and hepatitis caused by spleen deficiency and dampness. Astragalus injection is widely used in the clinical treatment of chest pain and heart pain, and the curative effect is definite. After research, the main effective components of its cardiovascular system activity are astragalus saponins, and pharmacological experiments h...
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IPC IPC(8): A61K47/34A61K31/7048A61K36/481A61K9/08A61K47/02A61P9/04A61P9/10A61P9/00A61P1/16A61K47/14
Inventor 刘近荣
Owner 山西振东泰盛制药有限公司