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Method for predicting retention time of gas chromatograph second order temperature programming chromatographic peak

A technology of temperature programming and retention time, applied in the field of analytical chemistry, can solve problems such as inability to guarantee the separation effect

Inactive Publication Date: 2009-08-19
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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Problems solved by technology

However, in actual work, only using the first-order temperature program cannot guarantee the best separation effect, and the second-order and multi-stage temperature program are effective ways to analyze complex systems

Method used

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  • Method for predicting retention time of gas chromatograph second order temperature programming chromatographic peak
  • Method for predicting retention time of gas chromatograph second order temperature programming chromatographic peak
  • Method for predicting retention time of gas chromatograph second order temperature programming chromatographic peak

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Embodiment

[0031] Take magnolia volatile oil as an example. Experimental equipment: gas chromatograph is Shimadzu GC-14C, chromatographic column: Supelco SPB TM -1 capillary column (30m×0.25mm×0.25μm), carrier gas: high-purity nitrogen with a purity >99.99%, gas: hydrogen, auxiliary gas: air, detector: hydrogen flame ion detector (FID).

[0032] by figure 1 Take No. 4 chromatographic peak as an example, according to the results obtained when the heating rate of the second-stage temperature program is 10°C / min and 12°C / min, it is predicted that its temperature increase rate in the second-stage temperature program is 14°C / min When the retention time of No. 4 chromatographic peak, the calculation process is as follows:

[0033] The first step is to set the first-order temperature programming conditions

[0034] According to the different boiling points of the components in the volatile oil of Magnolia magnolii and the reports of related literature, the first-order temperature-programmed ...

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Abstract

The invention relates to a method for predicting the retention time of gas phase chromatography second-order programming temperature-rise chromatographic peak, belonging to the technical field of analytical chemistry. The method predicts retention time values under other second-order programming temperature-rise gas phase chromatography conditions by the retention time value of target components in a sample to be detected under two preset second-order programming temperature-rise gas phase chromatography conditions. The method has the advantages that the predicted value of the chromatographic peak retention time has high accuracy, the workload is small, and the method provides a feasible approach for selecting optimum separation conditions of gas chromatography, and the like.

Description

technical field [0001] The invention relates to a method for predicting the retention time of a chromatographic peak in a second-order temperature program of gas chromatography, which belongs to the technical field of analytical chemistry. Background technique [0002] With the development of life science-related disciplines such as pharmacy, the composition of analysis objects faced by analysts is becoming more and more complex. Gas chromatography is a separation and analysis method with high efficiency, high selectivity, high sensitivity, simple operation and wide application. Temperature programming is an experimental technique widely used in gas chromatography. However, the determination of temperature raising conditions needs to be obtained through repeated exploration of experimental conditions, which lacks theoretical guidance and requires a lot of work. Therefore, if the retention time of chromatographic peaks under different heating conditions can be predicted, and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/30
Inventor 亓云鹏范国荣曲丽萍吴玉田
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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