Medical application of licorice flavonoids
A technology of licorice flavonoids and drugs, which is applied in the field of medicinal use of licorice flavonoids, can solve the problems of limited, low side effects, and side effects, and achieve the effect of less adverse reactions, less possibility, and strong anti-inflammatory effect
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[0020] 1. The effect of licorice flavonoids on acute lung inflammation in mice
[0021] Diseases such as ALI, ARDS, SARS, COPD, and asthma have a common animal model, that is, a mouse lung inflammation model induced by endotoxin lipopolysaccharide (LPS, Esherichia coli). We first simulated the clinical acute lung inflammation and established the animal model of this mouse. After using this model to study, we found that the medicine prepared by the licorice flavonoids of the present invention can reduce LPS with the dosage of 3mg / kg, 10mg / kg, and 30mg / kg. Induce the increase of TNF-α level in the lung tissue of the mouse ALI model, reduce the degree of neutrophil infiltration in the lung tissue, inhibit capillary permeability, reduce protein exudation and lung water content, reduce the MPO level of the BALF supernatant, and improve Pathological changes of lung tissue inflammation. These results suggest that licorice flavonoids have anti-inflammation, anti-oxidation, reducing p...
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