Medical application of licorice flavonoids

A technology of licorice flavonoids and drugs, which is applied in the field of medicinal use of licorice flavonoids, can solve the problems of limited, low side effects, and side effects, and achieve the effect of less adverse reactions, less possibility, and strong anti-inflammatory effect

Inactive Publication Date: 2009-09-09
ZHEJIANG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the drug treatment methods for the above diseases are limited, mainly the early application of glucocorticoids, and although glucocorticoids can inhibit the aggregation of inflammatory cells and the release of inflammatory mediators, they will also bring various types of side effects and Adverse reactions, such as suppression of the body's immune response, adverse effects on the body's metabolic function, water-salt balance, etc., and these overlap with the patient's symptoms, and long-term use of glucocorticoids also has serious adverse effects on various systems of the body , therefore, it is necessary to find effective drugs that inhibit the accumulation and release of inflammatory cells in the acute phase with lower side effects

Method used

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  • Medical application of licorice flavonoids
  • Medical application of licorice flavonoids
  • Medical application of licorice flavonoids

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Embodiment 1

[0020] 1. The effect of licorice flavonoids on acute lung inflammation in mice

[0021] Diseases such as ALI, ARDS, SARS, COPD, and asthma have a common animal model, that is, a mouse lung inflammation model induced by endotoxin lipopolysaccharide (LPS, Esherichia coli). We first simulated the clinical acute lung inflammation and established the animal model of this mouse. After using this model to study, we found that the medicine prepared by the licorice flavonoids of the present invention can reduce LPS with the dosage of 3mg / kg, 10mg / kg, and 30mg / kg. Induce the increase of TNF-α level in the lung tissue of the mouse ALI model, reduce the degree of neutrophil infiltration in the lung tissue, inhibit capillary permeability, reduce protein exudation and lung water content, reduce the MPO level of the BALF supernatant, and improve Pathological changes of lung tissue inflammation. These results suggest that licorice flavonoids have anti-inflammation, anti-oxidation, reducing p...

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Abstract

The invention provides an application of licorice flavonoids in preparing medicine for treating acute and chronic lung inflammatory diseases. The acute and chronic lung inflammatory diseases comprise acute lung Injury, acute respiratory distress syndrome, severe acute respiratory organ syndrome, chronic obstructive lung disease, asthma and the like. The licorice flavonoids preparation provided by the invention has strong antiinflammatory action and can coordinate or replace the application of hormone in treating diseases including acute lung Injury, acute respiratory distress syndrome, severe acute respiratory organ syndrome, chronic obstructive lung disease, asthma and the like. Compared with the hormone, the licorice flavonoids enjoys the characteristics and advantages that adverse reactions are few, possibility of triggering drug induced disease is slim. Licorice flavonoids is extracted from natural plants and can be prepared into health food for playing a supplementary role in improving symptoms caused by diseases.

Description

technical field [0001] The invention belongs to medicinal use, and relates to the medicinal use of licorice flavonoids, in particular to the application of licorice flavonoids in the preparation of medicines or health care products for treating acute pulmonary inflammatory diseases. Background technique [0002] In my country, licorice has a long history of medicinal use and has been widely used. Traditional medicine believes that it has the effects of benefiting qi and nourishing the middle, clearing heat and detoxifying, eliminating phlegm and relieving cough, relieving spasm and pain, and reconciling various medicines. There is a saying of "ten directions and nine herbs". Licorice is the root and rhizome of various plants of the leguminosae genus Glycyrrhiza Linn. According to the 2005 edition of the Pharmacopoeia of the People's Republic of China, there are three original plants, namely G.uralensis Fisch., G.inflate Bat, and G.glabraL. With the development of pharmacy ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61P11/00A61P11/06A23L1/29A23L33/00
Inventor 谢强敏董新威谢诒诚吴希美
Owner ZHEJIANG UNIV
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