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Agent for external application to the skin having excellent stability

一种外用制剂、皮肤的技术，应用在皮肤外用制剂领域，能够解决未研究配方等问题

Active Publication Date: 2009-09-09
KURARAY CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] On the other hand, it is not known that 4-alkylresorcinol prevents The viscosity of the composition is reduced and formulations using the composition in combination have not been studied

Method used

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  • Agent for external application to the skin having excellent stability
  • Agent for external application to the skin having excellent stability
  • Agent for external application to the skin having excellent stability

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] According to the following formulation, the components described in (A) were mixed and heated to 70°C, the mixture of component (B) heated to 70°C was added thereto, and then stirred using a homomixer to emulsify the mixture. A mixture of component (C) heated to 70°C was added thereto, and the entire system was cooled under stirring. After that, the mixture of component (D) was added thereto at 40°C, and the whole system was cooled to room temperature, thereby preparing the cream of Example 1.

[0086] In Comparative Example 1, repeat the same steps as in Example 1, just replace 4-n-butylresorcinol with water; in Comparative Example 2, repeat the same steps as in Example 1, just replace calcium chloride with water; In Comparative Example 3, repeat the same steps as in Example 1, but replace propylene glycol alginate with water; in Comparative Example 4, repeat the same steps as in Example 1, but replace 4-n-butylresorcinol with water and propylene glycol alginate.

[...

Embodiment 2-4

【0056】

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PUM

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Abstract

The present invention discloses an agent for external application to the skin which is hardly reduced in viscosity even when stored for a long period under extreme high temperature storage conditions and is therefore stable. The agent is of an emulsion-type, and comprises 1) an alginic acid polyhydric alcohol ester having an esterification degree ranging from 75 to 95% (e.g., alginic acid propylene glycol ester) and / or a salt thereof, 2) a polyvalent metal ion (e.g., a calcium ion); and 3) a 4-alkylresolcinol (e.g., 4-n-butylresolcinol) and / or a salt thereof.

Description

technical field [0001] [0001] The present invention relates to an external preparation for skin in the form of an emulsion, and more particularly to a method for improving storage stability under harsh storage conditions. Background technique [0002] [0002] The emulsified composition can contain both an oily component and an aqueous component, and thus is excellent as an external preparation for skin. In general, surfactants are used to prepare emulsions, but some low-molecular-weight surfactants may irritate the skin or may be partially decomposed to produce a substance that irritates the skin (Patent Document 1). Therefore, a technique of using a polymer having an emulsifying effect, such as an alkyl acrylate / alkyl methacrylate copolymer, instead of a low-molecular-weight surfactant has been developed (Patent Documents 2 and 3). However, in the emulsification technique using an alkyl acrylate / alkyl methacrylate copolymer, the emulsified composition is stabilized by ion r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/37A61K8/06A61K8/19A61K8/34A61Q19/00
CPCA61Q19/00A61K8/735A61K8/347A61K8/37A61K8/27
Inventor 赤松尚铃木将史酒井裕二
Owner KURARAY CO LTD
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