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Method for extracting ursolic acid from persimmon leaf by composite countercurrent method

A countercurrent method, ursolic acid technology, applied in the direction of drug combination, steroids, anti-toxins, etc., can solve the problems of complex process, insufficient extraction rate, and many steps, so as to reduce energy consumption and liquid treatment volume , the effect of using heat energy

Active Publication Date: 2011-04-13
GUILIN SANLENG BIOTECH
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

This method has many steps, the process is complicated, and the extraction rate is not high enough.

Method used

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  • Method for extracting ursolic acid from persimmon leaf by composite countercurrent method
  • Method for extracting ursolic acid from persimmon leaf by composite countercurrent method

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Embodiment Construction

[0036] Utilize the composite countercurrent method to extract ursolic acid from persimmon leaves, the preferred values ​​of steps and parameters are:

[0037] 1. Take the persimmon leaves in December and crush them into powder, and put them into an extraction container;

[0038] 2. Add ethyl acetate into the extraction vessel from the bottom of the extraction vessel, the volume ratio of the solvent to the persimmon leaf powder is equal to 3:1, and the extraction temperature is 70°C;

[0039] 3. Continuous leaching for 3 times, 120 minutes each time, refining the extract extracted for the first time, the specific process is: filtration, recovery of solvent, crude ursolic acid, dissolution and decolorization, concentrated crystallization, crude ursolic acid crystals, Recrystallization to obtain ursolic acid crystals, the slag of the first extraction is extracted for the second time, the second extraction is used as the extraction solvent for the first raw material, and the slag ...

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Abstract

The invention discloses a method for extracting ursolic acid from persimmon leaf by a composite countercurrent method, comprising the extraction by a countercurrent method. The method is characterized in that the composite countercurrent method is adopted for extraction; during the circular production, a plurality of groups of extraction containers are used in parallel; the extraction solution ofsecond or third time is taken as the first extraction solvent of new raw material; furthermore, only the extraction solution of the first raw material is turned to a refining procedure to carry out the refining operation; furthermore, the new solvent is added only when the extraction of the third time of the raw material is carried out. The method has the advantages that by adopting the compositecountercurrent method for extraction, the extraction yield is high; the multi-level composite use of the solvent leads the effective compositions to be leached out to the maximum degree and reduces the using amount of the solvent by 1 / 2 simultaneously; furthermore, the medical liquid treatment amount of the subsequent procedure is reduced quickly and greatly, and the energy consumption is effectively reduced.

Description

technical field [0001] The invention relates to a method for extracting ursolic acid, in particular to a method for extracting ursolic acid from persimmon leaves by a composite countercurrent method. Background technique [0002] Ursolic acid has a wide range of medicinal value, such as: anti-hypertensive, anti-atherosclerosis, anti-oxidation, anti-tumor, and may become a potential anti-HIV drug. There are many research articles on the extraction of total flavonoids from persimmon leaves, but there are few reports on the technology of extracting ursolic acid from persimmon leaves. At present, the extraction and separation of ursolic acid from persimmon leaves or other natural resources are refined by reflux extraction, column chromatography, or alkali dissolution and acid precipitation. [0003] Chinese patent 200510118223.9 discloses a method for extracting ursolic acid by the reflux method, which is to extract the pulverized persimmon leaves with low-carbon chain alcohol,...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07J63/00A61P9/12A61P9/10A61P39/06A61P35/00
Inventor 吕光政韦彩珠刘樟艳陈元胜梁昌祥陈莲
Owner GUILIN SANLENG BIOTECH