Application of chroman compound HEF-19 in preparing intestinal canal smooth muscle antispastic and antidiarrhoeal

A technology of HEF-19 and compounds, applied in the field of medicine

Inactive Publication Date: 2009-10-07
SHENYANG PHARMA UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0002] The chemical name of the chroman compound HEF-19 is 3,4-dihydro-7-[3-(diethylamino)-propoxy]chroman hydrochloride. It is a compound in the full series of compounds, and the anti-platelet aggregation activity has been preliminarily investigated. The results show that the compound has strong anti

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  • Application of chroman compound HEF-19 in preparing intestinal canal smooth muscle antispastic and antidiarrhoeal
  • Application of chroman compound HEF-19 in preparing intestinal canal smooth muscle antispastic and antidiarrhoeal
  • Application of chroman compound HEF-19 in preparing intestinal canal smooth muscle antispastic and antidiarrhoeal

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Embodiment 1

[0017] 1. Experimental materials

[0018] animal:

[0019] New Zealand rabbits, both male and female, weighing 2.0-2.5kg, provided by the Experimental Animal Center of Shenyang Pharmaceutical University, certificate number: Liaoshidongzi No. 033.

[0020] Hef-19: Purity>99%, provided by Organic Laboratory of Shenyang Pharmaceutical University.

[0021] 2. Experimental method

[0022] 1. Effect of HEF-19 on spontaneous activity of isolated small intestine of rabbits

[0023] After the tension of the specimen was stabilized, HEF-19 with different final concentrations (10 -6 mol / L, 10 -5 mol / L, 10 -4 mol / L) 0.1ml and solvent water, observe and record the change of small intestine autonomic contraction under each concentration, and record the change of tension and amplitude before and after administration. Taking the tension or amplitude before administration as 100%, the percentage of small intestine tension or amplitude after administration was calculated. The experimenta...

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Abstract

The invention relates to the field medical technology, and discloses the applications of chroman compounds HEF-19 in preparing intestinal canal smooth muscle antispastic and antidiarrhoeal. In the in vitro experiment of animals, HEF-19 can reduce tension and amplitude induced by spontaneous activities of isolated small intestine smooth muscle of a rabbit, and relax the contractions induced by acetylcholine, barium chloride, potassium chloride and histamine on isolated small intestine smooth muscle of the rabbit. Therefore, the compound can be used for preparing antispastic and antidiarrhoeal for treating intestinal canal smooth muscle spasm. The applications of the compound refer to the preparations of medicaments used for treating stomach/abdomen convulsive pain caused by various reasons,medicaments used for treating intestinal irritable syndrome, medicaments used for treating functional disturbance gastrointestinal tract caused by ulcerative colitis, and medicaments used for treating functional diarrhea caused by various reasons and the like.

Description

Technical field: [0001] The invention relates to the technical field of medicine, and relates to the use of a chroman compound HEF-19 for preparing an antispasmodic agent and an antidiarrheal agent for intestinal smooth muscle. Background technique: [0002] The chemical name of the chroman compound HEF-19 is 3,4-dihydro-7-[3-(diethylamino)-propoxy]chroman hydrochloride. It is a compound in the full series of compounds, and the anti-platelet aggregation activity has been preliminarily investigated. The results show that the compound has strong anti-platelet aggregation activity, but so far there has been no report on the effect of HEF-19 on relaxing intestinal smooth muscle. Application After various experimental screenings, it was found for the first time that the compound has antispasmodic and antidiarrheal effects on intestinal smooth muscle. [0003] The chemical name of the chroman compound HEF-19 is 3,4-dihydro-7-[3-(diethylamino)propoxy]chroman hydrochloride, and its...

Claims

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Application Information

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IPC IPC(8): A61K31/353A61P1/06A61P1/12A61P1/00
Inventor 付守廷胡春韦元元黄二芳朱玉莹
Owner SHENYANG PHARMA UNIVERSITY
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