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Child throat and tonsil particles

A technology for children and granules, applied in the fields of plant raw materials, respiratory diseases, inactive components of polymer compounds, etc., can solve the problems of poor compliance and large doses of children.

Active Publication Date: 2009-10-07
北京市医用生物制品中试基地
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0025] Since Xiaoer Yanbian Granules are mainly suitable for children, the existing traditional Chinese medicine preparations have defects such as large dosage and bitter taste, and poor compliance of children taking medicine, so there is a need to improve the existing preparations
[0026] The prior art teaches β-cyclodextrin inclusion technology, which is mainly used in the inclusion 2-3 of chemicals and volatile oils in pharmaceuticals to increase the solubility and stability of drugs, improve the bioavailability of drugs, and reduce the irritating, toxic and side effects, masking of bitterness, and powdering of liquid medicines, etc., but it has not been applied to the inclusion of Chinese herbal medicine extracts

Method used

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  • Child throat and tonsil particles
  • Child throat and tonsil particles
  • Child throat and tonsil particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1. Pharynx flat granules for children prepared by spray granulation

[0039] Chinese herbal medicine

[0040] name

place of origin

name

place of origin

name

place of origin

Honeysuckle

Henan

Shegan

Hebei

Golden fruit olive

Yunnan

bellflower

Anhui

Scrophulariaceae

zhejiang

Ophiopogon japonicus

sichuan

[0041] The Chinese medicine decoction pieces of honeysuckle, shegan, jinguolan, bellflower, scrophulariaceae and radix are produced by Beijing Shouer Chinese Medicine Decoction Pieces Co., Ltd.

[0042] The manufacturer of artificial bezoar is Wuhan Baicaoyuan Biochemical Pharmaceutical Co., Ltd., and the manufacturer of borneol is Guangzhou Huangpu Chemical Plant or Zhuzhou Matsumoto Linhua Co., Ltd.

[0043] Operating process and process conditions

[0044] 1. Extraction: decoct the six herbs of honeysuckle, golden fruit olive, platycodon grandiflorum, scrophulariaceae, R...

Embodiment 2

[0087] Example 2. Xiaoeryanbian granules mixed with excipients and granulated after the clear ointment was spray-dried

[0088] Process operation

[0089] 1. Extraction: decoct the six herbs of honeysuckle, golden fruit olive, platycodon grandiflorum, scrophulariaceae, Radix Ophiopogon japonicus and Shegan with water twice. Add 8 times the amount of water for the first time, 2.5 hours; add 6 times the amount of water for the second time, 1.5 hours. The decoction is passed through an 80-mesh sieve and combined.

[0090] 2. Concentration: Concentrate the filtrate under reduced pressure (at a temperature of 70-90°C) to a clear paste with a relative density of 1.20-1.25 (50°C), and submit the clear paste for inspection.

[0091] 3. Crushing and sieving:

[0092] 3.1. Pulverization: pulverize the mannitol, and the mesh number of the pulverizer is 100 mesh.

[0093] 3.2. Pass the dextrin through an 80-mesh sieve.

[0094] 4. After the clear paste is spray-dried, it is mixed wit...

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Abstract

The invention relates to Chinese medicine preparation field. Concretely, the invention relates to improved child throat and tonsil particles, and the the particles is prepared by combining clear paste and additives containing beta-cyclodextrin by spray pelletization process or by pelletization process after clear paste atomizing drying, wherein the dosage rate of clear paste to beta-cyclodextrin is 1:0.1. The child throat and tonsil particles of the invention decreas amount of additives, and reduce bitterness, more suitable for children.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations. Specifically, the present invention relates to improved Xiaoeryanbian granules, which are prepared by combining clear ointment with auxiliary materials containing β-cyclodextrin through a spray granulation process or a granulation process after spray drying the clear ointment. Background technique [0002] The main ingredients of Xiaoer Yanbian Granules are honeysuckle, golden fruit olive, artificial bezoar, bellflower, scrophulariaceae, Radix Ophiopogon japonicus, shegan and borneol. It is mainly used to clear away heat and sore throat, detoxify and relieve pain. It is used for sore throat, erosion of mouth and tongue, cough with phlegm, pharyngitis, laryngitis, and tonsillitis caused by excessive lung heat. Currently, there are two specifications of Xiaoer Yanbian Granules sold in the market, 8g and 4g per bag respectively. [0003] Pediatric Pharynx Flat Granule Speci...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K9/16A61K47/40A61P11/04A61K31/045A61K35/413
Inventor 童立芬
Owner 北京市医用生物制品中试基地
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