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Hazelnut element B, extracting method and pharmaceutical use thereof

A hazelin, the name of the technology, applied in the field of application in the preparation of drugs for the treatment of hyperlipidemia, to achieve a significant effect of curative effect

Inactive Publication Date: 2009-10-07
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] At present, there is no report on the extraction method and compound of hazelin B. This compound is a new compound and is isolated for the first time; the new medicinal use of this compound is discovered for the first time

Method used

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  • Hazelnut element B, extracting method and pharmaceutical use thereof
  • Hazelnut element B, extracting method and pharmaceutical use thereof
  • Hazelnut element B, extracting method and pharmaceutical use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] a. Extraction: Take 5.0kg of dried hazel leaves, soak them with 3 times the amount of 85% ethanol at room temperature for 24 hours, filter, recover the solvent, extract 3 times, combine the extracts, recover the solvent under reduced pressure to a relative density of 1.12, and filter , the filtrate was extracted with petroleum ether, chloroform, ethyl acetate and n-butanol successively, and the solvent was recovered under reduced pressure to dryness to obtain 25 g of n-butanol.

[0033] b. Separation: The obtained n-butanol part is subjected to silica gel column chromatography of 200 to 300 meshes, eluted with chloroform-methanol 1:1, the eluate is collected, and the solvent is recovered to obtain the crude hazelin B product with a yield of 0.011%. ,

[0034] c. Purification of hazelin B: take crude hazelin B and recrystallize it with methanol to obtain pure hazelin B: 0.5 g.

[0035] Identification: Spectroscopy method was used for structural identification.

[0036]...

Embodiment 2

[0051] a. Extraction: Take 5.0kg of dried hazel leaves, soak them with 4 times the amount of 75% ethanol at room temperature for 24 hours, filter, recover the solvent, extract 3 times, combine the extracts, recover the solvent under reduced pressure to a relative density of 1.15, and filter , The filtrate was sequentially extracted with petroleum ether, chloroform, ethyl acetate, and n-butanol, and the solvent was recovered under reduced pressure to dryness to obtain 28 g of n-butanol.

[0052] b. Separation: The obtained n-butanol part is subjected to silica gel column chromatography of 200 to 300 meshes, eluted with chloroform-methanol 1:5, the eluate of part B of hazelin is collected, and the solvent is recovered to obtain the crude product of hazelin A. Yield 0.013%.

[0053] c. Purification of hazelin B: the crude hazelin B was recrystallized with methanol to obtain pure hazelin A: 0.64 g.

Embodiment 3

[0055] a. Extraction: Take 5.0kg of dried hazel leaves, soak them in 5 times the amount of 95% ethanol at room temperature for 24 hours, filter, recover the solvent, extract 3 times, combine the extracts, recover the solvent under reduced pressure to a relative density of 1.14, and filter , the filtrate was sequentially extracted with petroleum ether, chloroform, ethyl acetate, and n-butanol, and the solvent was recovered under reduced pressure to dryness to obtain 30 g of n-butanol.

[0056] b. Separation: The obtained n-butanol part is subjected to silica gel column chromatography of 200 to 300 meshes, eluted with chloroform-methanol at 1:10, the eluate of hazelin B part is collected, and the solvent is recovered to obtain hazelin B crude product, Yield 0.016%.

[0057] c. Purification of hazelin B: take crude hazelin A and recrystallize it with methanol to obtain pure hazelin A: 0.7 g.

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Abstract

The present invention relates to a hazelnut element B, an extracting method and a pharmaceutical use thereof. The hazelnut element belongs to a novel compound and the pharmaceutical use. The Corylus heterophylla Fisch.ex Bess leaf is used as a raw material. Through alcohol extraction, organic solvent extraction, sililca gel column chromatography and recrystallization process, a novel compound is obtained. The chemical name of the novel compound is 1,3-dihydroxy-5,8-dimethoxy-2,4-bis(3-methylbut-2-enyl)-xanthen-9-one. The novel compound is called as hazelnut element B in short. The production rate is more than 0.01%. The hazelnut element B has a broad pharmaceutical use in preparing the medicine for treating hyperlipemia.

Description

technical field [0001] The invention relates to hazelin B, its extraction method, and its application in the preparation of medicines for treating hyperlipidemia. Background technique [0002] Flat hazel (Corylus heterophylla Fisch) is a plant in the genus Corylus heterophylla Fish. exBess. [0003] Hazel (Corylus heterophylla Fish.ex Bess.) is a plant of the genus Corlus in the family Beturaceae. It is native to my country and has a history of more than 6,000 years according to research. Due to the abundant wild resources of hazel, over the years my country has mostly used wild resources. With the rapid development of cultivation and the continuous development of the market, a small amount of cultivation has been carried out in some areas of my country in recent years. At present, there are 12 species of hazels cultivated in my country, including Corylus heterophylla Fisch, Corlus mandshurica Batal, and Corylus tibetica Batal. , Shanxi, Shandong, Henan and other places are...

Claims

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Application Information

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IPC IPC(8): C07D311/86A61K31/352A61P3/06
Inventor 刘金平李平亚卢丹薛健飞
Owner JILIN UNIV
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