Trichosanthes bark dropping pill and preparation method thereof
A technology of trichosanthes peel and dripping pills, which is applied in pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve problems such as inconvenient injections, poor patient compliance, and few side effects, and achieve quality Stable and controllable, improved bioavailability, and less side effects
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0026] 1, the preparation of Trichosanthes bark extract:
[0027] Take Trichosanthes medicinal material coarse powder, add 10 times the amount of water, soak for 0.5h, reflux at 100°C for 1h, filter the extract with double-layer gauze to obtain the first filtrate and filter residue, add 8 times the amount of water to the filter residue, and reflux at 100°C After 45 minutes, filter to obtain the second filtrate, combine the two filtrates, and concentrate under reduced pressure at 55°C and a vacuum of 0.08-0.1MPa.
[0028] 2. Preparation of dropping pills:
[0029] Weigh the materials according to the following proportions: 100 g of Trichosanthes bark extract, 300 g of matrix polyethylene glycol-6000. Put the matrix in a container, heat it in a water bath to melt, then add the medicinal material extract into the molten matrix, continue heating and stirring on the water bath until the mixture is uniform, pour it into the storage tank of the dropping pill machine, and keep the oi...
Embodiment 2
[0032] 1, the preparation of Trichosanthes bark extract:
[0033] Take the coarse powder of Trichosanthes melon, add 10 times the amount of water, soak for 0.5h, reflux at 55°C for 1h, filter the extract with double-layer gauze to obtain the first filtrate and filter residue, add 6 times the amount of water to the filter residue, and reflux at 100°C After 45 minutes, filter to obtain the second filtrate, combine the two filtrates, and concentrate under reduced pressure at 55°C and a vacuum of 0.08-0.1MPa.
[0034] 2. Preparation of dropping pills:
[0035] Weigh the materials according to the following proportions: Trichosanthes pipifolia extract 100g, matrix matrix polyethylene glycol-6000 300g. Put the matrix in a container, heat it in a water bath to melt, then add the medicinal material extract into the molten matrix, continue heating and stirring on the water bath until the mixture is uniform, pour it into the storage tank of the dropping pill machine, and keep the oil b...
Embodiment 3
[0038] Except that the preparation of Trichosanthes bark extract is following method, all the other are identical with embodiment 2.
[0039] Take the coarse powder of Trichosanthes rind, add 6 times the amount of hydrochloric acid solution with pH 1.0 to soak for 1 hour, ultrasonically treat at 250W, 250-300Hz for 45 minutes, filter, concentrate the filtrate to a thick paste, add 8 times the amount of pH 7.4 hydrochloric acid solution to the residue Soak in NaOH lye for 1h, ultrasonically treat at 250W, 250-300Hz for 45min, filter, concentrate the filtrate to a thick paste, add 5 times the amount of NaOH lye with pH 8.5 to soak for 1h, and ultrasonically Treat for 60 minutes, filter, concentrate the filtrate to a thick paste, and combine the thick paste for three times.
[0040] The appearance of Examples 1, 2, and 3 are brown pellets, with an average pellet weight of 0.0252 g, and the difference in pellet weight meets the requirements. At room temperature, it is hard, round ...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More