Application of Chinese medicine composition in preparation of medicine for treating atypical hyperplasia of gastric mucosa

A composition and gastric mucosal technology, applied in the field of traditional Chinese medicine applications, can solve the problems of undisclosed traditional Chinese medicine composition application, overexpression of oncogenes, drug damage, etc., and achieve the effects of less adverse reactions, definite curative effect, and prevention of gastric cancer.

Active Publication Date: 2009-11-18
HEBEI YILING MEDICINE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(3) Oncogene overexpression
(7) drug damage
The above-mentioned patent does not disclose the application of the traditional Chinese medicine composition in the treatment of gastric mucosal atypical hyperplasia

Method used

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  • Application of Chinese medicine composition in preparation of medicine for treating atypical hyperplasia of gastric mucosa
  • Application of Chinese medicine composition in preparation of medicine for treating atypical hyperplasia of gastric mucosa
  • Application of Chinese medicine composition in preparation of medicine for treating atypical hyperplasia of gastric mucosa

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] The raw material drug formula is:

[0055] Astragalus 250g Ligustrum lucidum 200g Ginseng 65g Ganoderma lucidum 65g Curcuma 132g

[0056] Atractylodes macrocephala (fried) 64g Scutellaria barbata 128g Gynostemma 256g Poria cocos 65g Gallinarum 30g

[0057] Snakeberry 128g, Baiying 128g, Yinchen 128g, Xu Changqing 128g

[0058] Hedyotis diffusa 128g Wood beetle 20g

[0059] The preparation method is:

[0060] (1), take the Chinese medicinal material according to the weight ratio of the crude drug, and select it;

[0061] (2) For ginseng and Ligustrum lucidum, add 8 times the amount of 70% ethanol to reflux and extract twice, the first time for 3 hours, and the second time for 2 hours, combine the extracts, recover the ethanol until there is no alcohol smell, ginseng, Ligustrum lucidum Residue for use;

[0062] (3) Curcuma, Atractylodes Rhizome (stir-fried), and Xu Changqing were combined to extract the volatile oil, the oil extraction time was 8 hours, the volatile ...

Embodiment 2

[0068] The raw material drug formula is:

[0069] Astragalus 360g Ligustrum lucidum 100g Ginseng 95g Ganoderma lucidum 30g Curcuma 195g

[0070] Atractylodes macrocephala (fried) 30g Scutellaria barbata 195g Gynostemma 120g Poria cocos 95g Gallinarum 15g

[0071] Snakeberry 195g Baiying 65g Yinchen 195g Xu Changqing 65g

[0072] Ground Beetle 30g Hedyotis diffusa 65g

[0073] The preparation method is:

[0074] (1), take the Chinese medicinal material according to the weight ratio of the crude drug, and select it;

[0075] (2), ginseng, Ligustrum lucidum, add 6 times the amount of 90% ethanol to reflux and extract for 4 hours, the ethanol is recovered from the extract until there is no alcohol smell, and the residues of ginseng and Ligustrum lucidum are set aside;

[0076] (3) Combine Curcuma, Atractylodes Rhizoma Atractylodes Rhizome (stir-fried), and Xu Changqing, add 4 times the amount of water to extract the volatile oil, the oil extraction time is 10 hours, collect th...

Embodiment 3

[0082] The raw material drug formula is:

[0083] Astragalus 120g Ligustrum lucidum 300g Ginseng 30g Ganoderma lucidum 95g Curcuma 65g

[0084] Atractylodes macrocephala 90g Scutellaria barbata 65g Gynostemma 360g Poria 30g Gallinarum 45g

[0085] Snakeberry 65g, Baiying 195g, Yinchen 65g, Xu Changqing 195g

[0086] Ground Beetle 10g Hedyotis diffusa 195g

[0087] The preparation method is:

[0088] (1), take the Chinese medicinal material according to the weight ratio of the crude drug, and select it;

[0089] (2) For ginseng and Ligustrum lucidum, add 10 times the amount of 50% ethanol to reflux and extract twice, the first time for 3 hours, and the second time for 2 hours, combine the extracts, recover the ethanol until there is no alcohol smell, ginseng, Ligustrum lucidum Residue for use;

[0090] (3) Merge Curcuma, Atractylodes Rhizoma Atractylodes Rhizome, and Xu Changqing, add 10 times the amount of water to extract the volatile oil, the oil extraction time is 6 ho...

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PUM

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Abstract

The invention discloses an application of a Chinese medicine composition in preparation of a medicine for treating the atypical hyperplasia of the gastric mucosa. The medicine is formed by combining Chinese medicines such as radix astragali, glossy privet fruit, and the like. The Chinese medicine composition has the efficacy of supplementing qi and nourishing yin, spleen kidney nourishing and eliminating stagnation activate meridians, is tangential to pathogenesis and is clinically used for treating the disease to obtain a better effect. The invention has rational proportion and small adverse reaction of the medicine, and can be used by patients for a long time.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition, in particular to the application of a traditional Chinese medicine composition in the preparation of medicine for treating dysplasia of gastric mucosa, which belongs to the field of traditional Chinese medicine application. Background technique [0002] Atypical hyperplasia of gastric mucosa or dysplasia (ATP) and intestinal metaplasia (IM) are seen in chronic atrophic gastritis (CAG). According to the unified understanding of the World Health Organization in 1978, ATP and IM are precancerous lesions, which are not included in traditional Chinese medicine. Corresponding name, at the Fifth National Symposium on Spleen-stomach Disease and Arthralgia Syndrome in 1989, the diagnostic name of "chronic atrophic gastritis" belonging to "stomach distension" was passed. Since ATP and IM are more common in deficiency syndrome, Dong called it "deficiency syndrome". swelling ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/906A61P1/04A61P35/00A61K35/37A61K35/64A61K35/57
Inventor 李向军安军永王超郑立发
Owner HEBEI YILING MEDICINE INST
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