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Liquid chromatography detector and flow controller therefor

A liquid chromatography and flow controller technology, applied in the field of liquid chromatography detectors and their flow controllers, can solve problems such as increasing sensitivity and reducing noise.

Inactive Publication Date: 2009-12-02
UNIV OF MISSOURI BOARD OF CURATORS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, such conventional detection devices with diffusers are not able to sufficiently reduce noise and increase sensitivity

Method used

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  • Liquid chromatography detector and flow controller therefor
  • Liquid chromatography detector and flow controller therefor
  • Liquid chromatography detector and flow controller therefor

Examples

Experimental program
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Effect test

example 1

[0029] now refer to Figures 2A-2C , shows the preamplifier chromatogram for 20 ppm hydrocortisone without the flow controller 130 of the present invention. These chromatograms exhibit the noise associated with conventional ELSD. Each of these chromatograms shows the signal detected at the preamplifier of the ELSD before any signal processing. Those of ordinary skill in the art will readily appreciate that these jagged peaks reduce the overall sensitivity of the ELSD, with a loss of accuracy due to the peaks having to be processed to remove the jagged peaks.

[0030] and Figures 2A-2C The spectrum of the opposite, Figures 3A-3C The preamplifier chromatogram for 20 ppm hydrocortisone shows the results of having the flow controller 130 of the present invention near the collision block 118 . The signal of these chromatograms showed a significant increase over the signal of the chromatogram without flow controller 130 . For example will Figure 2A and 3A In direct compari...

example 2

[0033] now refer to Figures 5A-5C , shows exemplary preamplifier and back panel chromatograms for 0.18 mg / mL ginkgolide B without the flow controller 130 of the present invention. The preamp color spectrum includes a lot of noise. Some noise was removed only after processing the signal, as shown in the corresponding rear panel chromatograms. However, this treatment reduces the sensitivity of the ELSD, which is not desired. Furthermore, even after rear panel processing, the Figures 5A-5C In each of , the color spectrum still includes quite a lot of noise.

[0034] on the contrary, Figures 6A-6C Preamplifier and back panel chromatograms for 0.18 mg / mL ginkgolide B with flow controller 130 are shown. These preamplifier spectra ( Figures 6A-6C ) is created by the flow controller 130, and with the corresponding spectrum created without the aid of the flow controller ( Figures 5A-5C ), exhibits very inconspicuous noise. Specifically, for example Figure 5A and 6A In d...

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PUM

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Abstract

A flow controller for use with a liquid chromatography detector. The flow controller includes a flow channel comprising an inlet portion, a control channel portion in communication with the inlet portion, and an outlet portion in communication with said control channel portion. The control channel portion has a cross-sectional area smaller than a cross-sectional area of a drift tube of the liquid chromatography detector for channeling the flow of droplets through the smaller cross-sectional area. The flow controller is shaped and sized to reduce pressure fluctuations and turbulence in the droplet stream of the liquid chromatography detector.

Description

Background technique [0001] Typically, liquid chromatography (LC) analysis is performed using evaporative light scattering detectors (ELSD), mass spectrometers, and charged aerosol detectors. In this device, a liquid sample is converted into droplets by a nebulizer. A carrier gas carries these droplets through the spray box, impact block, and drift tube. Conventional devices place collision blocks in the path of the droplet to intercept large droplets, which are collected and exit the drift tube through a discharge port. The remaining appropriately sized sample droplets pass through the drift tube, where they can be heated to help evaporate the solvent portion of the droplets. As the solvent portion of the droplet evaporates, the remaining non-volatile analyte is passed to a detection unit or detector for detection depending on the type of device utilized. In the detection unit of the ELSD, for example, the light scattering of a sample is measured. Thus, a variety of sampl...

Claims

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Application Information

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IPC IPC(8): G01N11/04
CPCG01N2030/847G01N30/84G01N30/74G01N2030/8494G01N30/02G01N11/04
Inventor 徐治
Owner UNIV OF MISSOURI BOARD OF CURATORS
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