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Method for simply preparing high-purity beta-Elemene

A high-purity technology for elemene, applied in the field of simple preparation of high-purity β-elemene, can solve the problems of high cost, complicated production equipment, and poor extraction stability of equipment

Inactive Publication Date: 2009-12-30
沈阳万爱普利德医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0010] The purpose of the present invention is to provide a kind of β-elemene containing β-elemene in order to overcome the existing problems in the prior art, such as the limitation of the raw material source of high-content β-elemene, complex and expensive production equipment, and poor extraction stability of instruments and equipment. A new method for the preparation of high-purity β-elemene raw materials from natural plants of ene

Method used

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  • Method for simply preparing high-purity beta-Elemene
  • Method for simply preparing high-purity beta-Elemene
  • Method for simply preparing high-purity beta-Elemene

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] A, get the natural herbal medicine curcuma tuber as raw material;

[0042] B, the medicinal material Zedoary is steam-distilled to obtain Zedoary volatile oil, wherein the content of β-elemene is 6.0%;

[0043] c, put the raw material obtained in b into the rectifying tower still to carry out rectification, the control vacuum degree is 5~6mm Hg, the temperature of the tower still is 123 ℃~124 ℃, when the reflux ratio is 1: 1, the removal temperature is at Impurity fractions below 75°C; control the reflux ratio to 3:1, collect fractions at a temperature of 77°C to 82°C, and obtain β-elemene with a content of 23.5%.

[0044] d. The 23.5% β-elemene obtained in c was extracted three times with 80% ethanol aqueous solution with double volume concentration, and the upper oil phase was collected.

[0045] e, the oil phase obtained in step d is extracted three times with an aqueous solution having an equal volume concentration of 1.5 mol / L silver nitrate, the lower layer of th...

Embodiment 2

[0048] a, taking the fresh leaves of natural plant Javanese citronella as raw material;

[0049] b. The medicinal material Javanese citronella is steam-distilled to obtain Javanese volatile oil, wherein the content of β-elemene is 5.0%;

[0050] c, put the raw material obtained in b into rectification tower still and carry out rectification, control vacuum tightness is 2~3mm Hg, the temperature of tower still is 116 ℃~117 ℃, when reflux ratio is 1: 1, removal temperature is in The impurity fraction below 75°C; the reflux ratio is controlled to be 3:1, and the fraction at a temperature of 78°C to 81°C is collected to obtain β-elemene with a content of 16.0%.

[0051] d. The 16.0% β-elemene obtained in c was extracted three times with a 70% ethanol aqueous solution with a quadruple volume concentration, and the upper oil phase was collected.

[0052] e, the oil phase obtained in step d is extracted three times with an aqueous solution of 2.5 mol / L silver nitrate with an equal v...

Embodiment 3

[0055] a, taking the fresh leaves of natural plant Solidago as raw material;

[0056] b. Obtaining Solidago volatile oil through supercritical extraction of the leaves of Solidago, wherein the content of β-elemene is 14.3%;

[0057] c, put the raw material obtained in b into the rectification tower still for rectification, control the vacuum to be 6-7mm Hg, the temperature of the tower still is 123-124°C, when the reflux ratio is 1:1, the removal temperature is 75 The impurity fraction below ℃; the reflux ratio is controlled to be 4:1, and the fractions with a temperature of 79°C to 82°C are collected to obtain β-elemene with a content of 40.6%.

[0058] d. The 40.6% β-elemene obtained in c was extracted three times with 60% ethanol aqueous solution with a triple volume concentration, and the upper oil phase was collected.

[0059] e, the oil phase obtained in step d is extracted three times with an aqueous solution having an equal volume concentration of 2.0 mol / L silver nit...

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Abstract

The invention provides a method for preparing high-purity beta-Elemene from natural plants containing beta-Elemene such as curcuma zedoary (root tubers or stem tubers of the curcuma zedoary), Cymbopogon citratus (fresh leaves of the Cymbopogon citrates), Solidago virgaurea (roots, stems, leaves, flowers and seeds of the Solidago virgaurea) and the like so as to improve production efficiency from the initial raw materials to the high-purity beta-Elemene and reduce production cost. Compared with the prior art, the method is mainly characterized in that: the roots, stems, leaves, flowers and seeds of the natural plants are taken as raw materials, and volatile oil of specific parts of the natural plants is prepared by methods for extracting different volatile oil, and then is rectified by a rectification method to prepare high-content beta-Elemene; then impurity components are removed by an ethanol extraction method and a silver nitrate complexing extraction method; finally the beta-Elemene with the content between 95.0 and 99.9 percent is prepared by distillation under reduced pressure; and the beta-Elemene not only can be prepared into oral administrative preparations such as emulsion oral liquid, capsules and the like, but also can be prepared into parenteral administrative preparations such as emulsion parenteral solution, injection, cutaneous permeable agents, lung spray preparations, suppositories and the like. The method has novel design of experimental methods, simple instruments and equipment, concise operation steps and obviously shortened operation time, improves production efficiency and is suitable for industrial production.

Description

Technical field: [0001] The invention relates to a simple preparation method for obtaining high-purity β-elemene. technical background: [0002] Elemene is isolated from zedoary oil and citronella oil, and has been widely used to treat cancer. The earliest anticancer drug was zedoary oil injection made from zedoary oil, which can only be used locally The treatment of cervical cancer by tumor drug administration has a long course of treatment and inconvenient administration operation, while other various cancers cannot be effectively treated with this injection. In order to solve the problem of the limitation of the use of zedoary oil injection, people have separated elemene with fixed proportioning components from zedoary oil and citronella oil to make elemene injection. In addition to local tumor administration and regional administration, the milk injection can also be injected intravenously, and can treat cervical cancer, brain tumor, digestive tract malignant tumor, mal...

Claims

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Application Information

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IPC IPC(8): C07C13/19C07C7/04C07C7/10A61K31/01A61P35/00
CPCY02P20/54
Inventor 孙敏鸽李淑斌项银娟周莉宁红
Owner 沈阳万爱普利德医药科技有限公司
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