Chitosan coating medicine slow release microsphere and preparation method thereof
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A technology of slow-release microspheres and chitosan, which is applied in the direction of drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., can solve problems such as easy oxidation, influence on curative effect, product color and performance changes, etc. The method is simple and easy to implement, and the effect of dispersion is good
Inactive Publication Date: 2010-01-06
HEBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY
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[0003] Because resveratrol, oxidized resveratrol, pterostilbene, and picatanol contain different numbers of phenolic hydroxyl groups in the molecules, they are easily oxidized in the air, resulting in changes in the color and performance of the product; and the phenolic hydroxyl groups The existence of the above-mentioned several compounds is also susceptible to the influence of pH, and complex changes may occur when they are compounded with other compounds as drugs or health products, affecting their own effective curative effect
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[0031]
[0032] Embodiment 1-6 is respectively the sustained-release microspheres of different medicines coated with chitosan and preparation method thereof
[0033] The structure of each slow-release microsphere is as follows: figure 1 , figure 2 As shown, it includes a spherical capsule shell 2 and a powdery core medicine coated in the capsule shell 2 . The capsule shell is a condensation product of chitosan and glutaraldehyde, and the core drug components are resveratrol, oxidized resveratrol, pterostilbene, piceatanol, resveratrol, oxidized resveratrol .
[0034] The microsphere is a rounded sphere with a particle size of 2-100 microns, the surface is not smooth, with wrinkles 4, and there are pores 3 on the shell wall.
[0035] In embodiment 1-embodiment 6, the ratio of raw materials for making the active ingredients of sustained-release microspheres is shown in the table. The preparation method of sustained-release microspheres is carried out according to the fol...
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Abstract
The invention discloses a chitosan coating medicine slow release microsphere and a preparation method thereof. The chitosan coating medicine slow release microsphere comprises a condensate capsule shell of chitosan and glutaric dialdehyde, core medicine resveratrol, oxidative resveratrol, pterostilbene or white cedar alcohol, wherein the core medicine resveratrol, the oxidative resveratrol, the pterostilbene or the white cedar alcohol are coated into the capsule shell. The preparation method is simple and easy, the preparation cost is low, the microsphere envelop rate is 10-50 percent, the microsphere is round and has good dispersivity, the stability of the original medicine is increased, and the chitosan coating medicine slow release microsphere realizes the function of medicine slow control and release and can be conveniently matched with other medicines. The chitosan coating medicine slow release microsphere is suitable for preparing a slow release formulation of medical resveratrol, oxidative resveratrol, pterostilbene and white cedar alcohol.
Description
technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, in particular to a chitosan-coated medicine slow-release microsphere and a preparation method thereof. Background technique [0002] Resveratrol (3,4',5-trihydroxystilbene), oxidized resveratrol (2,4,3',5'-tetrahydroxystilbene), pterostylbene (3 , 5-dimethoxy-4′-hydroxystilbene), picatanol (3,4,3’,5’-tetrahydroxystilbene), which belong to active non-flavonoid polyphenols, widely exist in Among natural foods or plants, a large number of studies have shown that they have significant anti-inflammatory, anti-oxidant, anti-bacterial, anti-free radical and inhibition of platelet aggregation, anti-thrombotic, anti-hyperlipidemia, and can be used for arteriosclerosis, coronary heart disease, viral hepatitis , AIDS, cancer and other diseases prevention and treatment. [0003] Because resveratrol, oxidized resveratrol, pterostilbene, and picatanol contain different numbers ...
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