Ivermectin nanoemulsion drug combination and preparation method thereof

A technology of ivermectin and nano-drugs, applied in the directions of drug combination, pharmaceutical formulation, anti-infective drugs, etc., can solve the problems of poor stability, insoluble ivermectin in water, etc., and achieve stable content and good thermodynamic stability. , the effect of reducing toxicity

Active Publication Date: 2010-01-13
LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the present invention, ivermectin is made into nanoemulsion, which greatly improves the therapeutic effect of ivermectin, and at the same time solves the shortcomings of ivermectin that it is extremely difficult to dissolve in water and has poor stability

Method used

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  • Ivermectin nanoemulsion drug combination and preparation method thereof
  • Ivermectin nanoemulsion drug combination and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] 1) Weigh 1.0 g of ethyl oleate, 7.5 g of Tween-80, 2.5 g of 1,2-propanediol, and 0.5 g of ivermectin for each drug component.

[0041] 2) At room temperature of 25°C, first place the above-mentioned weight of ethyl oleate, Tween-80, 1,2-propylene glycol, and ivermectin on a constant temperature magnetic stirrer, stir at 300-500rpm for 10min, and mix well until the ivermectin is completely dissolved and the system is transparent.

[0042] 3) Slowly add double-distilled water to the mixture, and stir while adding; the viscosity of the system is small at the beginning, and as the amount of water added increases, the system will become viscous, and at this time the system may appear liquid crystal phase or water For the oil-in-oil nanoemulsion, continue to drop and stir continuously. When the water content reaches 13.5g, the system will suddenly become thinner, the fluidity will increase, and it will be completely transparent. At this time, the ivermectin nanoemulsion drug ...

Embodiment 2

[0044] 1) Weigh 0.5 g of ethyl oleate, 6.0 g of Tween-80, 2.0 g of 1,2-propanediol, and 0.5 g of ivermectin for each drug component.

[0045] 2) At room temperature of 25°C, first place the above-mentioned weight of ethyl oleate, Tween-80, 1,2-propylene glycol, and ivermectin on a constant temperature magnetic stirrer, stir at 300-500rpm for 10min, and mix well until the ivermectin is completely dissolved and the system is transparent.

[0046] 3) Slowly add double-distilled water to the mixture, and stir while adding; the viscosity of the system is small at the beginning, and as the amount of water added increases, the system will become viscous, and at this time the system may appear liquid crystal phase or water For the oil-in-oil nanoemulsion, continue to drop and stir continuously. When the water content reaches 16.0g, the system will suddenly become thinner, the fluidity will increase, and it will be completely transparent. At this time, the ivermectin nanoemulsion drug ...

Embodiment 3

[0048] 1) Weigh 1.5 g of ethyl oleate, 7.0 g of Tween-80, 3.5 g of 1,2-propanediol, and 0.5 g of ivermectin for each drug component.

[0049] 2) At room temperature of 25°C, first place the above-mentioned weight of ethyl oleate, Tween-80, 1,2-propylene glycol, and ivermectin on a constant temperature magnetic stirrer, stir at 300-500rpm for 10min, and mix well until the ivermectin is completely dissolved and the system is transparent.

[0050] 3) Slowly add double-distilled water to the mixture, and stir while adding; the viscosity of the system is small at the beginning, and as the amount of water added increases, the system will become viscous, and at this time the system may appear liquid crystal phase or water For the oil-in-oil nanoemulsion, continue to drop and stir continuously. When the water volume reaches 12.5g, the system will suddenly become thinner, the fluidity will increase, and it will be completely transparent. At this time, the ivermectin nanoemulsion drug wil...

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Abstract

The invention discloses an ivermectin nanoemulsion drug combination. Oil-in-water type nanoemulsion consisting of ethyl oleate, Tween-80, 1,2- propylene glycol and ivermectin is prepared from being diluted by double distilled water. The ivermectin nanoemulsion drug combination greatly improves the effect of ivermectin in resisting parazoon, enhances the dissolubility, safety and bioavailability and is a high-efficiency antiparasitic nano level medicinal preparation with convenient use and wide ways of administration.

Description

technical field [0001] The invention belongs to the field of veterinary medicine, and relates to a medicine capable of resisting animal parasites, in particular to an ivermectin nanoemulsion pharmaceutical composition and a preparation method thereof. Background technique [0002] Ivermectin (Ivermectin, hereinafter referred to as IVM) is a semi-synthetic macrolide antibiotic, which is a dihydrogen reduction product of avermectin. It is the most excellent anthelmintic in the abamectin family and is widely used in animal husbandry production. However, its clinical application is difficult due to its extremely low water solubility, very poor storage stability and strong toxicity. Contents of the invention [0003] In view of the defects and shortcomings of the above-mentioned low water solubility and poor storage stability of ivermectin, the object of the present invention is to provide a nanoemulsion drug containing ivermectin for anti-animal parasite in veterinary medicin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/107A61K47/34A61K31/7048A61P33/14A61K47/26
Inventor 张继瑜李剑勇周绪正吴培星刘根新牛建荣魏小娟李金善
Owner LANZHOU INST OF ANIMAL SCI & VETERINARY PHARMA OF CAAS
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