New application of exenatide acetate and medicine aiming at new application
A technology of exenatide and new use, applied in the field of medicinal chemistry, can solve serious problems, poor curative effect, concealment and other problems, and achieve the effect of overall disease recovery, improvement of vascular and nerve function, and relief of diabetes manifestations
Inactive Publication Date: 2010-02-10
JIANGSU WANBANG BIOPHARMLS +1
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Problems solved by technology
The clinical manifestations of diabetic patients with coronary heart disease are more serious and hidden than those of non-diabetic coronary heart disease patients, and because the pathological changes are more extensive and serious than those of non-diabetic coronary heart disease patients, the curative effect of conventional drug treatment is poor
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[0029] 100ml Exenatide Injection contains the following components:
[0030] Exenatide 25mg
[0031] Mannitol 2.7g
[0032] Chlorobutanol 0.5g
[0033] Glacial acetic acid 0.105g
[0034] Trihydrate and sodium acetate 0.171g
[0035] Add water for injection to 100ml.
[0036] Exenatide injection is prepared according to the following steps:
[0037] Step 1: Dissolve the excipients chlorobutanol (preservative), mannitol (isotonic agent), glacial acetic acid and sodium acetate trihydrate (buffer) in sequence with water for injection according to the prescription amount and move them into the batching tank for injection. The amount of water used should be more than 75% of the total volume of the liquid medicine;
[0038] Step 2: After the excipients are completely dissolved, take an appropriate amount of exenatide solution and water for injection, dissolve the exenatide and move it into the batching tank, and stir evenly;
[0039] Step 3: Add water for injection to the tot...
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The invention relates to the field of pharmaceutical chemistry, in particular to a new application of exenatide acetate and medicine aiming at the new application. The new application of exenatide acetate is that the exenatide acetate is taken as a medicine used for preventing and curing diabetes and coronary disease. The invention also provides a medicine aiming at the new application. The medicine contains active constituent (exenatide acetate) of 0.005-0.4g / 100ml and appropriate amount of isotonic agent. The invention has the advantages that the exenatide acetate has better curative effecton patients suffering from diseases of diabetes and coronary disease than on patients suffering from one or none of the two diseases of diabetes and coronary disease. The exenatide acetate not only relieves the symptom of diabetes of patients, but also ameliorates the function of nervi vascularis, thus facilitating the complete recovery of patients.
Description
technical field [0001] The present invention relates to the field of medicinal chemistry, in particular to a new application of exenatide and a medicine for the new application, that is, exenatide is used to prepare and treat and prevent diabetes mellitus complicated with coronary heart disease and the medicine thereof. Background technique [0002] Exenatide (also known as Exenatide or Exenatide) is a synthetic exendin-4, which is an analogue of human glucagon-like peptide-1 (GLP-1). The sequence partially overlaps with the amino acid sequence of GLP-1, so it has the same physiological function as GLP-1. When exenatide binds to pancreatic GLP-1 receptors, it can stimulate pancreatic β cells to secrete insulin, thereby reducing fasting and postprandial blood sugar in patients with type II diabetes and slowing down the progressive decline of pancreatic β cell function. Exenatide is also known as an incretin agonist because it mimics the glucose-regulating effect of GLP-1. ...
Claims
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IPC IPC(8): A61K38/17A61P3/10A61P9/10
Inventor 徐娟乔德水周颖杨杰蔡爱军高雪芹
Owner JIANGSU WANBANG BIOPHARMLS