Coumaronochromones compound and preparation and application thereof

A technology of chromone compounds and coumarones, which is applied in the direction of active ingredients of heterocyclic compounds, organic chemistry, and drug combination, and can solve the problems of less research on chemical ingredients and no reported application of Dahongpao
CN101648959AActive Publication Date: 2010-02-17BASILEA PHARM CHINA LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
BASILEA PHARM CHINA LTD
Publication Date
2010-02-17

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Abstract

The invention discloses a coumaronochromones compound as shown by a formula 1. Pharmacological experiments show that the coumaronochromones compound has significant inhibitory action on the proliferation of B lymphocytes and T lymphocytes, and can be used for preparing immunosuppressive agents or medicaments for treating various immunologic diseases such as rheumatoid arthritis, lupus erythematosus and the like, and the medicaments for treating B cell type chronic lymphocytic leukemia. The invention also provides a preparation method.
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Description

Technical field:

[0001] The present invention relates to natural medicinal chemistry, in particular to isoflavone derivatives extracted and separated from the stem of Dahongpao [Myrsine Africana L.]—coumaronochromones (Coumaronochromones) compounds and its preparation method and preparation method for immunotherapy Inhibitor or treatment of various immune diseases, such as rheumatoid arthritis, lupus erythematosus and preparation of drugs for treating B-cell chronic lymphocytic leukemia. Background technique:

[0002] Coumaronochromones (Coumaronochromones) are isoflavone derivatives. It is known that naturally occurring plant isoflavones exhibit a wide range of biological activities, including anti-oxidation, regulation of signal transduction and enzyme activity; Inhibition of mitosis and cytotoxicity; increase capillary permeability; increase cell adhesion; increase the response of vascular smooth muscle to vascular relaxants; stimulate estrogen receptors, etc. These biol...

Claims

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