Application of ADDA and/or DMTA in preparing medicine for improving expression level of gamma-globin
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- NANJING UNIV
- Publication Date
- 2010-02-24
- Estimated Expiration
- Not applicable · inactive patent
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Abstract
Description
technical field
[0001] The invention belongs to the technical field of biomedicine and relates to ADDA (adenosine-2', 3'-diaaldehyde, 2', 3'-dialdehyde adenosine) and / or DMTA (5'-deoxy-5' (methyl-thio) adenosine , 5'-deoxy-5'-methylthiol adenosine), especially the application of ADDA and / or DMTA in the preparation of drugs for improving the expression of γ-globin, and in the preparation of drugs for the treatment of β-thalassemia and sickle cell anemia, hematopoietic system disorders or tumor-induced anemia drugs. Background technique
[0002] Hemoglobin in adults consists of two α-globin subunits and two β-globin subunits (α2β2). The human β-like globin gene cluster is located on the short arm of chromosome 11 and contains five sequentially arranged globin genes (ε, G gamma, A γ, δ, β), encoding β-like globin to synthesize hemoglobin. During human individual development, each globin gene is strictly turned on and off according to specific developmental stages and tissue...