Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Slow-release composition containing tamsulosin and preparation thereof

A slow-release composition, the technology of tamsulosin, which is applied in the direction of drug combination, medical preparations of non-active ingredients, cardiovascular system diseases, etc., can solve the problems of sudden release of sustained-release preparations, etc.

Inactive Publication Date: 2010-03-17
BEIJING TRADE STAR MEDICAL TECH
View PDF1 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention provides a tamsulosin long-acting preparation that can release slowly in vivo, and can adjust the particle ratio of different release rates according to the required release degree, and solves the problem that the slow-release preparation may cause burst release

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Slow-release composition containing tamsulosin and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] prescription:

[0021] Preparation of pellet core Composition mg / capsule

[0022] Tamsulosin 0.2

[0023] Microcrystalline Cellulose 25

[0024] Talc powder 10

[0025] Methacrylate -

[0026] Ethyl Acrylate Total 120

[0027] polymer

[0028] Purified water 80

[0029] Stearic acid 34

[0030] The preparation process is as follows:

[0031] 1. Tamsulosin is dissolved in an appropriate amount of solvent and mixed evenly with microcrystalline cellulose.

[0032] 2. Add one or more polymers and necessary auxiliary agents to the above mixture.

[0033] 3. Add the water dispersion of the polymer and make 1.0-1.5mm granules in a centrifugal granulator.

[0034] 4. The prepared granules are dried in a blast drying oven at 40°C-90°C for 4-12 hours to make them contain an appropriate amount of water.

[0035] 5. Prepare the dispersion for coating and add necessary additives.

[0036] 6. Coat...

Embodiment 2

[0039] prescription:

[0040] Preparation of pellet core Composition mg / capsule

[0041] Tamsulosin 0.2

[0042] Microcrystalline Cellulose 15

[0043] Talc powder 10

[0044] Methacrylic acid-propylene

[0045] 135

[0046] Ethyl Acetate Copolymer

[0047] Purified water 80

[0048] Stearic acid 46

[0049] Preparation process is with embodiment 1.

Embodiment 3

[0051] prescription:

[0052] Preparation of pellet core Composition mg / capsule

[0053] Tamsulosin 0.2

[0054] Microcrystalline Cellulose 18

[0055] Talc powder 10

[0056] Methacrylic acid-ethyl acrylic acid

[0057] 30

[0058] Ester Copolymer

[0059] Purified water 80

[0060] Stearic acid 12

[0061] Methacrylic acid-ethyl acrylic acid

[0062] Coating 25

[0063] Ester Copolymer

[0064] Ethyl acrylate and methacrylic 8

[0065] Methyl acrylate copolymer

[0066] Triethyl citrate 0.5

[0067] Talc powder 2

[0068] Purified water 45

[0069] Preparation process is with embodiment 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a slow-release composition containing tamsulosin and preparation thereof; and a slow-release micro-pill preparation which is prepared by adding a certain thinning agent and retarding agent has the release rate being consistent with the need.

Description

technical field [0001] The technical field of the present invention relates to a preparation method of a controlled-release pharmaceutical composition of tamsulosin or a pharmaceutically acceptable salt thereof. Background technique [0002] Tamsulosin is an α-adrenoceptor blocker with selectivity for α-receptors in human prostaglandins. It is a pharmaceutically active substance with a-adrenergic blocking activity disclosed in EP34432 and USP4731478, and can be used for treating cardiac insufficiency and benign prostatic hyperplasia. [0003] Pharmacokinetic studies of tamsulosin have shown that tamsulosin is absorbed in the small intestine and is almost completely bioavailable. [0004] The sustained-release formulations reported so far are mostly integral systems, but they have some serious drawbacks. This delivery system can cause drug dumping with serious consequences, and gastric emptying is variable relative to larger single-dose systems, depending on the availabilit...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/16A61K9/48A61K31/18A61K47/32A61K47/36A61K47/38A61K47/44A61P9/00A61P13/08
Inventor 张耀春
Owner BEIJING TRADE STAR MEDICAL TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com