Compounds of phorbol esters and methods of use

A technology of phorbol ester and composition, applied in the field of cell pathology, can solve severe nausea, decreased bone marrow function, toxicity and other problems
CN101677542BInactive Publication Date: 2016-05-25BIOSUCCESS BIOTECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
BIOSUCCESS BIOTECH CO LTD
Publication Date
2016-05-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention provides methods and compositions comprising crotyl esters or crotyl ester derivatives for the treatment of cytopathic diseases. Cytopathic diseases can be caused by various means, for example, viral infection, such as HIV and AIDS, or the development of neoplastic lesions in mammalian subjects. The methods and compositions of the present invention are effective for inhibiting new HIV infection, upregulating viral expression from latent provirus, inhibiting HIV-induced cytopathic effects, downregulating HIV receptors, and increasing Th1 cytokine expression , reducing Th2 cytokine expression, increasing ERK phosphorylation, inducing apoptosis in malignant tumor cells, remission induction, remission maintenance, use as a chemotherapeutic agent, and for alleviating the symptoms of cytopathic diseases and the opportunistic infections that accompany these diseases. The present invention provides additional compositions and methods employing crotyl esters or derivatives thereof in combination with at least one additional agent, such as an agent for a course of HAART, a therapeutic agent for treating opportunistic infections due to HIV, or is a chemotherapeutic agent to generate a more effective therapeutic tool against cytopathic diseases in mammalian subjects.
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Description

[0001] 【Related application】

[0002] This application claims priority to US Provisional Patent Application Serial No. 60 / 898,810, filed January 31, 2007, which is hereby incorporated by reference in its entirety. 【Technical field】

[0003] The present invention relates generally to the field of cytopathic diseases. More specifically, the present invention relates to a compound comprising a phorbol ester and a method of using a phorbol ester for the treatment of a cytopathic condition and the disease causing the cytopathic condition. 【Background technique】

[0004] Phorbol is a naturally occurring organic compound from plants, which belongs to diterpenes. Phorbol was first isolated in 1934 as a hydrolyzate of croton oil produced from the seeds of croton (cortontiglium), a leafy shrub native to Southeast Asia in the Euphorbiaceae family. Various esters of phorbol have important biological properties, including the well-known diacylglycerols and the ability to initiate prote...

Claims

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