Unlock instant, AI-driven research and patent intelligence for your innovation.

New use of isosorbide mononitrate in preparing medicine for increasing endometrial thickness

A technology of isosorbide dinitrate and endometrium, which is applied in the field of medicine and can solve the problems of increasing endometrium and uterine glands

Inactive Publication Date: 2011-09-28
SICHUAN WEIXIN MEDICAL TECH
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there are no related reports on the use of isosorbide mononitrate to increase the thickness of the endometrium, promote the development of uterine glands and stroma, and thus improve the receptivity of the endometrium

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • New use of isosorbide mononitrate in preparing medicine for increasing endometrial thickness
  • New use of isosorbide mononitrate in preparing medicine for increasing endometrial thickness
  • New use of isosorbide mononitrate in preparing medicine for increasing endometrial thickness

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of embodiment 1 suppository

[0027] Table 1

[0028] Numbering

Substrate (mg)

ISMN (mg)

Propylene glycol (mg)

Azone (mg)

Propylene Glycol + Azone (mg)

Grain weight (mg)

1

Semi-synthetic fatty acid glycerides (52.23)

2.88

55.11

2

Glycerin gelatin (48.16)

2.88

51.04

3

P-188(45.94)

2.88

48.82

4

Semi-synthetic fatty acid glycerides (50.03)

2.88

2.2

55.11

5

Glycerin gelatin (46.12)

2.88

2.04

51.04

6

P-188(43.99)

2.88

1.95

48.82

7

Semi-synthetic fatty acid glycerides (51.13)

2.88

1.1

55.11

8

Glycerin gelatin (47.14)

2.88

1.02

51.04

9

P-188(44.96)

2.88

0.98

48.82 ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
particle diameteraaaaaaaaaa
Login to View More

Abstract

The invention belongs to the technical field of medicine, particularly relates to a new use of isosorbide 5-mononitrate and a corresponding new dosage form suitable for the new use, and concretely relates to a use of isosorbide 5-mononitrate in preparing drug for improving the receptive performance of endometrium. The improvement of the receptive performance of endometrium is concretely realized through repairing and improving the endometrium, or through prompting the development of uterus glandular organ, or through prompting the development of uterus mesenchyma. In order to adapt to the four new uses, the prepared drug is vagina local drug feeding preparation, namely, preparation which takes isosorbide 5-mononitrate with effective amount as active components and is prepared through adding accessories which are allowable in pharmacy. The isosorbide 5-mononitrate not only can exert excellent medical effects of prompting the development of endometrium tissues and improving the receptive performance of endometrium, but also can effectively avoid the side effect that isosorbide 5-mononitrate lowers blood pressure after giving drug in vagina, and provides a new choice for clinical application.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a new application of isosorbide mononitrate and a new dosage form corresponding to the new application. Background technique [0002] One of the keys to the successful implantation of fertilized eggs is that the state of endometrial receptivity (uterine receptivity) is synchronized with the development of fertilized eggs. Endometrial receptivity is a comprehensive state in which the endometrium accepts embryo implantation, including the thickness of the endometrium, the developmental state of the glands and stroma, and the blood supply state of the endometrium. [0003] According to the statistics of the United States, 15% of the patients who received IVF-ET treatment clinically were caused by endometrial dysplasia and poor receptivity. Due to the family planning policy in China, a large number of women of childbearing age have undergone abortion for many times. The endometri...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/34A61K9/02A61P15/00A61P15/08
Inventor 高翔
Owner SICHUAN WEIXIN MEDICAL TECH