Preparation and process of qingkailing eye drops

An eye drop and ophthalmology technology, applied in the field of traditional Chinese medicine preparations, can solve problems such as adverse reactions and unsatisfactory treatment effects, and achieve the effect of solving adverse reactions and solving unsatisfactory treatment effects.

Inactive Publication Date: 2010-06-02
山东施尔明眼科医院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the present invention, the Qingkailing medicinal material is extracted and separated to make eye drops for the first time, which not only solves the occurrence of adverse reactions during intravenous administration of Qingkailing injection, but also solves the problem of unsatisfactory therapeutic effects of systemic administration, and meets the needs of clinical ophthalmologists. The need for topical medication

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] prescription:

[0024] Cholic acid 13g

[0025] Mother of Pearl 200g

[0026] Hyodeoxycholic Acid 15g

[0027] Gardenia 100g

[0028] Buffalo horn 100g

[0029] Banlangen 800g

[0030] Baicalin 20g

[0031] Honeysuckle 80g

[0032] Sodium Hyaluronate 2g

[0033] Sodium chloride 0.5g

[0034] Ethylparaben 0.5g

[0035] Appropriate amount of PH regulator

[0036] Appropriate amount of purified water or water for injection

[0037]

[0038] Qingkailing Eye Drops 1000ml

[0039] Preparation method:

[0040] (1) Radix isatidis 800g, decoct twice with water, 1 hour each time, combine the decoction, filter, concentrate the filtrate to 200ml, add ethanol to make the alcohol content reach 60%, refrigerate, filter, recover the ethanol from the filtrate, add water, Refrigerate and set aside.

[0041] (2) Gardenia 100g, decoct twice with water, the first time for 1 hour, the second time for 0.5 hours, combine the decoction, concentrate...

Embodiment 2

[0048] prescription:

[0049] Cholic acid 13g

[0050] Mother of Pearl 200g

[0051] Hyodeoxycholic Acid 15g

[0052] Gardenia 100g

[0053] Buffalo horn 100g

[0054] Banlangen 800g

[0055] Baicalin 20g

[0056] Honeysuckle 80g

[0057] Sodium Hyaluronate 2g

[0058] Sodium chloride 1g

[0059] Ethylparaben 0.5g

[0060] Appropriate amount of PH regulator

[0061] Appropriate amount of purified water or water for injection

[0062]

[0063] Qingkailing Eye Drops 1000ml

[0064] Preparation method:

[0065] (1) Radix isatidis 800g, decoct twice with water, 1 hour each time, combine the decoction, filter, concentrate the filtrate to 200ml, add ethanol to make the alcohol content reach 60%, refrigerate, filter, recover the ethanol from the filtrate, add water, Refrigerate and set aside.

[0066] (2) Gardenia 100g, decoct twice with water, the first time for 1 hour, the second time for 0.5 hours, combine the decoction, concentrate...

Embodiment 3

[0073] prescription:

[0074] Cholic acid 13g

[0075] Mother of Pearl 200g

[0076] Hyodeoxycholic Acid 15g

[0077] Gardenia 100g

[0078] Buffalo horn 100g

[0079] Banlangen 800g

[0080] Baicalin 20g

[0081] Honeysuckle 80g

[0082] Sodium Hyaluronate 2g

[0083] Sodium chloride 2g

[0084] Ethylparaben 0.5g

[0085] Appropriate amount of PH regulator

[0086] Appropriate amount of purified water or water for injection

[0087]

[0088] Qingkailing Eye Drops 1000ml

[0089] Preparation method:

[0090] (1) Radix isatidis 800g, decoct twice with water, 1 hour each time, combine the decoction, filter, concentrate the filtrate to 200ml, add ethanol to make the alcohol content reach 60%, refrigerate, filter, recover the ethanol from the filtrate, add water, Refrigerate and set aside.

[0091] (2) Gardenia 100g, decoct twice with water, the first time for 1 hour, the second time for 0.5 hours, combine the decoction, concent...

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PUM

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Abstract

The invention relates to the preparation and a process of qingkailing eye drops. The qingkailing eye drops are a medicine for treating the inflammatory eye diseases such as the conjunctivitis, the keratitis, the iritis, the endophthalmitis and the like. In the invention, the qingkailing medicinal materials are prepared into eye drops by extracting a separator, optimizing the auxiliary materials and improving the process, a mode of local administration is adopted, the medicine directly reaches an acting position, and the effective medicine concentration in eyes is increased. The invention prevents the adverse reaction of qingkailing from occurring when venous injection is carried out for administration, solves the problem of non-ideal curative effect of the administration of the whole body and meets the requirement of local medicine application of clinical ophthalmology.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine preparations, and in particular relates to a medicine for treating ophthalmic diseases. The invention also relates to Qingkailing eye drops and a preparation method thereof. Background technique [0002] Qingkailing injection is a traditional Chinese medicine compound preparation developed on the basis of the famous ancient prescription "Angong Niuhuang Pill". At present, "Qingkailing" has various dosage forms, such as injection and freeze-dried powder injection. Granules, tablets, oral liquid, etc. The main ingredients are cholic acid, mother-of-pearl powder, hyodeoxycholic acid, gardenia, buffalo horn powder, isatidis, baicalin, and honeysuckle. Its functions and indications are heat-clearing and toxic substances removing, reducing phlegm and dredging collaterals, refreshing the mind and resuscitating the mind. For fever, coma, stroke hemiplegia, unconsciousness patients, such as acu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/744A61K9/08A61P27/02A61P29/00A61P31/00A61K31/7048A61K35/56A61K35/32A61K31/575A61K35/618
Inventor 毕宏生解孝锋郭俊国胡兵李朝峰
Owner 山东施尔明眼科医院
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