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Application of nonpathogenic edwarsiella tarda

A retarded Edwardian, non-pathogenic technology, applied in the field of immunology and microbiology, to achieve the effect of simple application, high protection rate and simple preparation process

Inactive Publication Date: 2010-06-09
INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The inventor's research group and other researchers have reported several effective vaccines against Edwardsiella tarda in the laboratory, but these vaccines are all derived from pathogenic Edwardsiella tarda, based on non-pathogenic Edwardsiella tarda Vaccines have not yet been reported

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0012] Non-pathogenic Edwardsiella tarda has immunoprotective effect on pathogenic Edwardsiella tarda infection. The non-pathogenic Edwardsiella tarda is Edwardsiella tarda 15947 (Tan YP, Lin Q, Wang XH, Joshi S, Hew C, Leung KY.Comparative proteomic analysis of extracellular proteins ofEdwardsiella tarda.Infect Immun 2002; 70: 6475-80.). Non-pathogenic virulence tests showed that the half-lethal dose (LD50) of 15947 and other typical pathogenic Edwardsiella tarda was infected with Trichogastertrichopterus (a fish), and the half-lethal dose (LD50) of 15947 was the typical pathogenic Edwardsiella tarda Bacteria 50-500 times, thus 15947 is classified as non-pathogenic Edwardsiella tarda.

[0013] The bacterial suspension of non-pathogenic Edwardsiella tarda has immune protective effect on pathogenic Edwardsiella tarda infection. Specifically, Edwardsiella tarda 15947 (purchased from American Type Culture Collection, No.: ATCC 15947) was cultured overnight in LB liquid medium; ...

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Abstract

The invention relates to an application of nonpathogenic edwarsiella tarda, belonging to the fields of immunology and microbiology. The nonpathogenic edwarsiella tarda has immune and protective effect on the infection of pathogenic edwarsiella tarda and high protective action on the pathogenic edwarsiella tarda and also has easy preparation and immune operation without any processing process.

Description

technical field [0001] The invention relates to the fields of immunology and microbiology, in particular to the application of non-pathogenic Edwardsiella tarda. Background technique [0002] Edwardsiella tarda (Edwardsiella tarda) is an important aquaculture biological pathogen, which can infect a variety of seawater and freshwater fish, including flounder, turbot, tilapia, red sea bream, eel, etc. cause huge economic losses. In addition, in addition to fish, Edwardsiella tarda can infect humans and terrestrial animals, causing acute gastroenteritis, wound infection, septicemia, etc. in humans; therefore, this bacterium is a typical human / animal / fish comorbid pathogens. For the prevention and treatment of tardive Edwards' disease, except for an inactivated vaccine recently used in South Korea, there is no other commercial vaccine in the world. The inventor's research group and other researchers have reported several effective vaccines against Edwardsiella tarda in the la...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/02A61P31/04
Inventor 孙黎程爽
Owner INST OF OCEANOLOGY - CHINESE ACAD OF SCI
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