Total sesquiterpene lactone extract of centipeda minima, preparation method and application thereof

A technology of sesquiterpene lactones and goose-buying herbivores, applied in the field of goose-buying total sesquiterpene lactones and its preparation, can solve the problem of goose-buying without new active sesquiterpene lactones The patents and literatures of the anti-tumor effective parts of grasses have not been found, etc., to achieve the effect of inhibiting tumor cell proliferation and high yield
CN101732383AInactive Publication Date: 2010-06-16JINAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
JINAN UNIVERSITY
Publication Date
2010-06-16
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention provides a total sesquiterpene lactone extract of centipeda minima, a preparation method and application thereof. The preparation method comprises the following steps: crushing dried total centipeda minima, and extracting centipeda minima volatile oil by a supercritical carbon dioxide extracting method; and enriching the centipeda minima volatile oil through macroporous adsorption resin column chromatography or silica gel column chromatography to obtain the total sesquiterpene lactone extract of the centipeda minima. According to the method, the total sesquiterpene lactone with effect of inhibiting tumor proliferation is extracted from Chinese medicament centipeda minima and is enriched for the first time; the extract is rich in short-leaf geraniin; the extract contains at least nine sesquiterpene lactone compounds, wherein the angelic acid centipeda minima and the isobutyric acid centipeda minima are new active sesquiterpene lactone compounds; by the preparation method, the yield is high; the method is suitable for industrialized production; and the extract has the effect of inhibiting tumor cell proliferation, and can be used for preparing various medicaments or health-care products with anti-tumor effect.
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Description

technical field

[0001] The invention belongs to the field of preparation of active ingredients of traditional Chinese medicines, and in particular relates to an extract of total sesquiterpene lactones of goosebubivorous and its preparation method and application. Background technique

[0002] Goose does not eat grass is the whole plant with flowers of Centipeda minima (L.) A.Br.et.Aschers, a plant of Compositae. Goose does not eat grass and is used as medicine. There are also records. In my country, geese do not eat grass and are mainly produced in Zhejiang, Hubei, Jiangsu, Guangdong and other places, and are also distributed in Guangxi, Henan, Jiangxi, Fujian, Anhui and other places. The herbal medicine was recorded in the 2000 and 2005 editions of "Chinese Pharmacopoeia" respectively.

[0003] The chemical components of goose herbivore mainly include volatile oils, terpenes, flavonoids and sterols, among which flavonoids and sesquiterpenoids are considered to be the acti...

Claims

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