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External preparation for treating abdominal pain and women's menorrhalgia, preparation method thereof, and quality control method thereof

A technology for external preparations and dysmenorrhea, applied in the field of external preparations, can solve the problems of difficult radical cure, normal morphological and biochemical examinations, and high incidence, and achieve rapid onset of effect, improved bioavailability, and high bioavailability Effect

Inactive Publication Date: 2010-06-16
徐朋 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented new formula describes different ways how drugs like zinc oxazole act differently when mixed together or applied externally during treatment procedures such as injection into muscles (treating arthritis). By combining these two types of substances separately, they become one mixture before being added to another formulation. These mixtures have improved efficacy compared to each other alone due to their combination's unique benefits. Additionally, this method allows for quicker release over time while keeping the desired chemical content inside. Overall, this novel composition provides effective treatments against inflammable joint diseases caused by bacterial flora activity.

Problems solved by technology

The technical problem addressed in this patented text is how to develop effective therapies against viscerocele due to insurgence caused by excessive bleeding during pregnancy without causing harmful side effects like negative pulmonary emphysema.

Method used

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  • External preparation for treating abdominal pain and women's menorrhalgia, preparation method thereof, and quality control method thereof
  • External preparation for treating abdominal pain and women's menorrhalgia, preparation method thereof, and quality control method thereof
  • External preparation for treating abdominal pain and women's menorrhalgia, preparation method thereof, and quality control method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Embodiment 1 gets the raw material of following mass percentage:

[0070] Stearic acid 6.0%

[0071] Stearyl Alcohol 2.0%

[0072] Proe-A100 2.0%

[0073] Isopropyl Palmitate 5.0%

[0074] Propylene Glycol 10.0%

[0075] Glycerin 5.0%

[0076] Imidazolidinyl urea 0.3%

[0077] Carbomer 934P 0.8%

[0078] Clonidine Hydrochloride 0.1%

[0079] Galangal Oil 1.0%

[0080] Cyperus oil 1.0%

[0081] Potassium hydroxide appropriate amount

[0082] Deionized water balance.

[0083] Preparation method: Mix stearic acid, glycerin, stearyl alcohol, and isopropyl palmitate about 1 / 2 of the weight evenly, heat to 65°C-90°C, and completely dissolve to obtain oil phase A; mix 1 / 2 of the weight Mix Proe-A100, propylene glycol, imidazolidinyl urea, carbomer 934P and part of water and heat to 65℃~90℃ to obtain water phase B; add phase A to phase B, stir to obtain a milky white liquid, stir and cool to obtain a cream Substrate C: Dissolve clonidine hydrochloride with the rest ...

Embodiment 2

[0084] Embodiment 2 gets the raw material of following mass percentage:

[0085] Stearic acid 8.0%

[0086] Stearyl Alcohol 2.0%

[0087] Proe-A100 3.0%

[0088] Isopropyl Palmitate 5.0%

[0089] Imidazolidinyl urea 0.3%

[0090] Propylene Glycol 10%

[0091] Glycerin 5.0%

[0092] Carbomer 934P 0.6%

[0093] Clonidine Hydrochloride 0.1%

[0094] Galangal Oil 1.0%

[0095] Cyperus oil 1.0%

[0096] Appropriate amount of potassium hydroxide

[0097] Purified water balance.

[0098] Preparation method: Mix stearic acid, glycerin, stearyl alcohol, and isopropyl palmitate about 1 / 2 of the weight evenly, heat to 65°C-90°C, and completely dissolve to obtain oil phase A; mix 1 / 2 of the weight Mix Proe-A100, propylene glycol, imidazolidinyl urea, carbomer 934P and part of water and heat to 65℃~90℃ to obtain water phase B; add phase A to phase B, stir to obtain a milky white liquid, stir and cool to obtain a cream Substrate C: Dissolve clonidine hydrochloride with the rest of...

Embodiment 3

[0099] Embodiment 3 gets the raw material of following mass percentage:

[0100] Stearic Acid 4.0%

[0101] Stearyl Alcohol 2.0%

[0102] M68 emulsifying wax 2.0%

[0103] Propylene Glycol 10.0%

[0104] Menthol 0.5%

[0105] Glycerin 5.0%

[0106] Imidazolidinyl urea 0.3%

[0107] Carbomer 940 0.5%

[0108] Clonidine Hydrochloride 0.1%

[0109] Galangal Oil 1.0%

[0110] Cyperus oil 1.0%

[0111] Potassium hydroxide appropriate amount

[0112] Double distilled water remaining.

[0113] Preparation method: Mix stearic acid, glycerin, stearyl alcohol, and M68 emulsifying wax about 1 / 2 of the weight evenly, heat to 65°C-90°C, and completely dissolve to obtain oil phase A; mix 1 / 2 of the weight of Proe- Mix A100, propylene glycol, imidazolidinyl urea, carbomer 934P with some water and heat to 65°C-90°C to obtain water phase B; add phase A to phase B, stir to obtain milky white liquid, stir and cool to obtain cream base C Dissolve clonidine hydrochloride with the water...

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Abstract

The invention provides a compound preparation prepared from lesser galangal rhizome oil, nutgrass galingale rhizome oil and clonidine hydrochloride, which is an external preparation for treating abdominal pain. Clinical tests prove that the prepared emulsifiable paste preparation has good treatment effects on derangement of vitality and blood, and irregular cycles, abdominal pain during menstruation, hypochondriac pain, abdominal distension and the like caused by the derangement of vitality and blood when applied to abdomen. The invention also carries out a series of related experiments such as percutaneous absorption experiments of the clonidine hydrochloride, and determination tests of the clonidine hydrochloride in blood concentration, which further affirms medicinal quality control and clinical effects.

Description

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Claims

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Application Information

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Owner 徐朋
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