Preparation method of bone inducing porous titanium artificial bone

An osteoinductive, porous titanium technology, applied in the field of biomedical materials, can solve problems such as speeding up the bone healing process, and achieve the effects of speeding up the bone healing process, convenient operation, and overcoming brittleness

Active Publication Date: 2010-06-23
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The purpose of the present invention is to provide a new method of surface activation with simple process and low cost to prepare artificial bone with osteoinductive porous titanium in view of the shortcomings of the above-mentioned osteoinductive porous titanium artificial bone preparation method and the broad application prospects for bone tissue repair. Inducible porous titanium artificial bone to further speed up the bone healing process

Method used

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  • Preparation method of bone inducing porous titanium artificial bone
  • Preparation method of bone inducing porous titanium artificial bone
  • Preparation method of bone inducing porous titanium artificial bone

Examples

Experimental program
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Effect test

Embodiment 1

[0034] The porous titanium block prepared by the slurry foaming method is machined into a sample with a length of 4 mm, a width of 5 mm, and a height of 12 mm. The pore size is mainly distributed in the range of 100-700 μm, and the average large pore size is 270 μm. The pore wall is rough and has The micropores of 2-70 microns are distributed on the walls of the macropores. The samples were ultrasonically cleaned with petroleum ether, acetone, absolute ethanol and deionized water for 20 minutes respectively, rinsed with deionized water, and then dried at room temperature to obtain the porous titanium artificial bone. Put the cleaned porous titanium artificial bone into an acid solution made of 98wt% sulfuric acid, 38wt% hydrochloric acid and deionized water with a volume ratio of 1:1:2, and place it in an oven at 70°C for 1 hour; take it out and use Rinse it with deionized water, then put it into 6M / L sodium hydroxide solution, keep it at 70°C for 5 hours, then rinse it gently...

Embodiment 2

[0037] The porous titanium block prepared by the slurry foaming method is machined into a sample with a diameter of 4 mm and a height of 10 mm. The pore size is mainly distributed in the range of 100-700 μm, and the average large pore size is 320 μm. The pore wall is rough, with 2- Micropores of 70 microns are distributed on the walls of large pores. The samples were ultrasonically cleaned with petroleum ether, acetone, absolute ethanol and deionized water for 20 minutes respectively, rinsed with deionized water, and then dried at room temperature to obtain the porous titanium artificial bone. Put the cleaned porous titanium artificial bone into the acid solution made of 55wt% hydrofluoric acid, 65wt% nitric acid and deionized water with a volume ratio of 1:10:89, treat it at room temperature for 90 seconds, take it out and place it in the Ultrasonic cleaning in deionized water for 15 minutes, then rinsed with deionized water and dried at room temperature; then placed in 30wt%...

Embodiment 3

[0039] The porous titanium alloy block prepared by the slurry foaming method is machined into a cube sample with a side length of 5mm. The pore size is mainly distributed in the range of 100-700μm, the average macropore size is 450μm, and the pore wall is rough. There are 2 -80 micron micropores are distributed on the walls of the macropores. The samples were ultrasonically cleaned with petroleum ether, acetone, absolute ethanol and deionized water for 20 minutes respectively, rinsed with deionized water, and then dried at room temperature to obtain the porous titanium artificial bone. Put the cleaned porous titanium artificial bone into the acid solution made of 55wt% hydrofluoric acid, 65wt% nitric acid and deionized water with a volume ratio of 1:10:89, treat it at room temperature for 90 seconds, take it out and place it in the Ultrasonic cleaning in deionized water for 15 minutes, then rinsed with deionized water and dried at room temperature; then placed in 30wt% hydroge...

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Abstract

The invention relates to a preparation method of bone inducing porous titanium artificial bone. The method comprises the following steps: a porous titanium block is processed into a required shape and is washed; the surface is activated; the porous titanium block is put into acid solution which is prepared by sulfuric acid, hydrochloric acid and deionized water to be processed and then is put into alkali solution of sodium hydroxide; or put into acid solution which is prepared by hydrofluoric acid, nitric acid and deionized water to be processed and is then put into hydrogen peroxide solution; or put into acid solution which is prepared by hydrofluoric acid, nitric acid and deionized water to be processed and is then put into hydrogen peroxide solution which contains tantalum pentachloride; the method is characterized in that the surface of the porous titanium can be activated uniformly without pre-depositing a calcium phosphate layer, when being soaked in simulated body fluid at 36.5DEG C, bone-like apatite can be induced to deposit in 28 days; and bone inductivity can be given to the porous titanium artificial bone. The bone inducing porous titanium artificial bone is used for repairing, replacing or reinforcing bone tissue and can reinforce the regeneration of the bone tissue and the interfacial bond of the implant site; and the process is simple and the operation is convenient.

Description

technical field [0001] The invention relates to a biomedical material preparation technology, in particular to a new preparation method of an osteoinductive porous titanium artificial bone, which belongs to the field of biomedical materials. Background technique [0002] From a clinical point of view, an ideal bone replacement repair material should have excellent mechanical properties, good biocompatibility, osteoconductivity, and osteoinductivity. [0003] Calcium phosphate bioceramic materials represented by hydroxyapatite (HA) are similar to the inorganic components of natural bone, not only have good biocompatibility and osteoconductivity, but also calcium phosphate ceramics with specific porous structure have osteoinductive properties. It can induce bone formation in a non-bone environment without the addition of growth factors or osteoblasts. However, due to its low strength, high brittleness and poor fatigue resistance in physiological environments, it is limited to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/06A61L27/56
Inventor 赵朝勇范红松李虎张兴栋
Owner SICHUAN UNIV
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