Method for preparing meclofenoxate hydrochloride sterile bulk drug

The technology of meclofenxe hydrochloride and raw material medicine is applied in the field of preparation of aseptic raw material medicine of central stimulant meclofen axetil hydrochloride, and can solve the problems of easy hydrolysis of the raw material of meclofen axetil hydrochloride of filter, easy blockage of pipelines and the like, Achieve the effect of low cost, stable process and low moisture content of finished products
CN101747215AInactive Publication Date: 2010-06-23YAOPHARMA CO LTD
4 Cites 5 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
YAOPHARMA CO LTD
Publication Date
2010-06-23
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
Patent Text Reader

Abstract

The invention relates to a method for preparing a meclofenoxate hydrochloride sterile bulk drug, which is characterized in that a meclofenoxate hydrochloride sterile finished product is obtained by the following steps: dissolving meclofenoxate hydrochloride in isopropanol in a certain mixture ratio, then decoloring and carrying out aseptic filtration and decompression concentration, and then devitrifying, filtering and drying. The product prepared by the method has more stable quality and simple process, thereby being suitable for industrial big production.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a method for preparing a central stimulant drug meclofenoxate hydrochloride aseptic bulk drug. Background technique

[0002] Meclofenoxate hydrochloride (Meclofenoxate), chemical name 2-(dimethylamino) ethyl p-chlorophenoxy acetate hydrochloride, was artificially synthesized by Professor Thuillier of the French National Center for Scientific Research in 1957. The product obtained by the esterification of phenoxyacetic acid (p-chlorphenoxyacetic acis) and dimethylaminoethanol (dimethylaminoethanol). Clinically, meclofenoxate hydrochloride is a central nervous system stimulant drug that has been used for many years. It is mainly used for the treatment of traumatic brain injury coma, neonatal hypoxia, and alcoholism, and can be used to control the symptoms caused by deep sleep and low awakening alert point. Enuresis in children, etc.

[0003] Regarding the synthetic preparation method of meclofenoxate hydrochloride, the Japanese...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More