Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of hyperin in preparation of medicament for treating climacteric syndrome and senile dementia

A technology for hyperoside and senile dementia, which is applied in the field of biomedicine and can solve problems such as large side effects

Inactive Publication Date: 2010-06-30
凌沛学
View PDF0 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drugs that improve cognitive function and promote brain metabolism are often used clinically, such as carbamate, gamma amino acid, etc., and calcium ion antagonists: Sibeline, nimodipine, etc. Blockers or anti-anxiety or antidepressant drugs, but with more side effects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of hyperin in preparation of medicament for treating climacteric syndrome and senile dementia
  • Application of hyperin in preparation of medicament for treating climacteric syndrome and senile dementia
  • Application of hyperin in preparation of medicament for treating climacteric syndrome and senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The pharmacological experiment of embodiment 1 hyperin to climacteric syndrome

[0021] 1.1 Experimental materials

[0022] 1.1.1 Experimental drug hyperin, made into 5% and 1% suspensions with distilled water before use. The H-estradiol radioimmunoassay kit was produced by Shanghai Biological Products Institute of the Ministry of Health. Acanthopanax tablets are prepared into 15% suspension with distilled water before use.

[0023] 1.1.2 Experimental animals Wistar rats, weighing 350-400 grams. Male and female.

[0024] 1.2 Experimental method 80 Wistar rats, 40 rats in the testosterone test group. All were male, and the 40 rats in the estradiol group were all female, and they were randomly divided into a normal saline group and three groups of large, medium and small doses of hyperin capsules. The doses were 0.1g / kg, 0.2g / kg, 0.4 g / kg; Acanthopanax group 0.4g / kg. Each group was gavaged continuously for 14 days. After the animals in each group were gavaged with l...

Embodiment 2

[0029] Example 2 Observation of the effect of hyperoside on vascular dementia model

[0030] 1 Materials and methods

[0031] 1.1 Animals: 40 healthy and clean SD rats, half male and half male, weighing 200-250g

[0032] 1.2 Drugs:

[0033] For hyperin, a suspension with a concentration of 0.05 g / ml was prepared with double distilled water during the experiment. Xidezhen is the positive control drug, 1mg / tablet. The tablets were crushed and dissolved in double-distilled water to prepare a suspension with a concentration of 0.0625 mg / ml through an ultrasonic cell pulverizer. After the drug is prepared, store it in a 4°C water tank for later use, and shake it well before use.

[0034] 1.3 Establishment of vascular dementia rat model

[0035] The thread bolt adopts a nylon fishing line with a diameter of 0.237 mm, and the head end is covered with nail polish, and is marked at 2 cm from the head end. After the rat is anesthetized by intraperitoneal injection of 10% chloral hy...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a new application of hyperin, in particular to an application in the preparation of a medicament for treating climacteric syndrome and senile dementia.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new drug application of hyperoside, in particular to the application of hyperin in the preparation of drugs for treating menopause syndrome and senile dementia. Background technique [0002] Hyperin (Hyperin, Hyperoside, Hyp), also known as quercetin-3-O-13-D galactopyranoside, belongs to flavonol glycosides. The aglycone is quercetin, and the glycosyl is galactopyranose, which is connected to the glycosyl by the 3-position O atom of quercetin through a β-glycosidic bond. Widely present in various plants, such as the fruits and whole plants of Hypericaceae, Rosaceae, Platycodonaceae, Labiatae, Berberidaceae, Rhododendronaceae, Sunflower, etc. Its chemical structural formula is shown in the accompanying drawings of the description. [0003] Modern pharmacological research shows that hyperoside has a variety of pharmacological activities. Generally speaking, the pharmacological effects ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/7048A61P15/12A61P25/28
Inventor 张玲凌沛学尚立霞吴永霞曲延伟
Owner 凌沛学
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com