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Preparation process of effective part of flower of abelmoschus manihot-total flavone extractive and new use thereof

An effective part, the technology of hollyhock flower, which is applied in the field of biomedicine and can solve the problems of large side effects

Inactive Publication Date: 2010-06-30
凌沛学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Drugs that improve cognitive function and promote brain metabolism are often used clinically, such as carbamate, gamma amino acid, etc., and calcium ion antagonists: Sibeline, nimodipine, etc. Blockers or anti-anxiety or antidepressant drugs, but with more side effects
However, there is no relevant pharmacological or clinical literature report on the treatment of climacteric syndrome, senile dementia, and depression with the total flavonoids of hollyhock flower.

Method used

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  • Preparation process of effective part of flower of abelmoschus manihot-total flavone extractive and new use thereof
  • Preparation process of effective part of flower of abelmoschus manihot-total flavone extractive and new use thereof
  • Preparation process of effective part of flower of abelmoschus manihot-total flavone extractive and new use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1 Preparation of effective parts of hollyhock flowers—total flavonoids extract

[0015] Add an appropriate amount of 80% ethanol to the hollyhock flower, extract once, extract for 2 hours, combine the extracts, filter, concentrate the filtrate into a concentrated solution with a relative density of 1.13-1.16 at 60°C, add an appropriate amount of water to sink for 24 hours, and filter with suction. Concentrate to the corresponding volume, pass through a macroporous adsorption resin column, use alcohol-water gradient elution, water elution 3 column volumes, 10% and 30% ethanol each elution 3 column volumes, 70% ethanol elution 1 column volume . The eluate is concentrated, dried and pulverized to obtain the total flavonoid extract of the marshmallow flower, and the total flavonoid content is 65%.

Embodiment 2

[0016] Example 2 Preparation of Capsules of Effective Fractions of Total Flavonoids of Melhock Flowers

[0017] Take 250g of the extract of effective fractions of total flavonoids from hollyhock flowers, 50g of magnesium stearate, pass through an 80-mesh sieve, mix well, dry granulate, fill 1000 capsules, and each capsule contains 250mg of effective fractions from total flavonoids from hollyhock flowers. Usage: 2 capsules each time, three times a day.

Embodiment 3

[0018] Example 3 The preparation of the active fraction tablet of total flavonoids of hollyhock flower

[0019] Take 250g of the effective part extract of total flavonoids of hollyhock flower and 45g of microcrystalline cellulose, mix well, wet granulate with ethanol, and pass through a 20-mesh sieve. Add 5 g of magnesium stearate, mix evenly, and press to form 1000 tablets with a tablet weight of 0.3 g / tablet, each containing 250 mg of active parts of total flavonoids from hollyhock flowers. Usage: 2 tablets each time, three times a day. Example 4 Preparation of effective fraction granules of total flavonoids of hollyhock flower

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PUM

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Abstract

The invention provides a preparation process of an effective part of flower of abelmoschus manihot-a total flavone extractive and a new use thereof, in particular relating to the use in preparing medicines for treating climacteric syndrome, Alzheimer disease and depression.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular refers to a new drug application of an effective part of hollyhock flower-total flavonoids extract, in particular the application in the preparation of drugs for treating menopause syndrome, senile dementia and depression. Background technique [0002] Menopausal syndrome (neurasthenia), senile dementia, and depression are all common diseases related to the central nervous system. Modern pathological mechanism studies have shown that the above three diseases are all related to cerebral ischemia, especially those caused by cerebral ischemia. Post-stroke depression and cerebral ischemic dementia (also known as vascular dementia) account for the vast majority of depression and dementia, becoming one of the major diseases in today's society. With the aggravation of various stress factors, such as accelerated pace of life, aging population, and intensified social competition, the incidence...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P15/12A61P25/24A61P25/28A61K133/00
Inventor 张玲凌沛学尚立霞曲延伟吴永霞
Owner 凌沛学
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