Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

New crystalline form of hydrochloric acid Ivabradine and preparation method thereof

A technology of ivabradine hydrochloride and ivabradine, which is applied in the field of new crystal forms of ivabradine hydrochloride and its preparation, and can solve problems not described in detail

Inactive Publication Date: 2014-05-07
BEIJING D VENTUREPHARM TECH DEV
View PDF10 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this reference does not detail the conditions for obtaining in a reproducible manner a form of ivabradine exhibiting those characteristics

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • New crystalline form of hydrochloric acid Ivabradine and preparation method thereof
  • New crystalline form of hydrochloric acid Ivabradine and preparation method thereof
  • New crystalline form of hydrochloric acid Ivabradine and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: Ivabradine hydrochloride in W-crystalline form

[0015] 1.0 g of ivabradine hydrochloride was added to 30 mL of acetone and 2 mL of methanol for dissolution under reflux, and the filtrate was allowed to stand for crystallization. Then pump and filter, and wash the filter cake with a small amount of acetone. The filter cake was vacuum dried at 85°C to constant weight. A 0.85 g sample of crystal form W was obtained. The melting point is 196.5-197.7°C.

[0016] The powder X-ray diffraction pattern is shown in Figure (1).

[0017]

[0018]

Embodiment 2

[0019] Embodiment 2: pharmaceutical composition

[0020] For the preparation of 1000 tablets, wherein each tablet contains 5 mg of ivabradine base, using the following formula 5.39 g of the compound of Example 1, 60.0 g of lactose, 20.0 g of microcrystalline cellulose, and 1.0 mg of magnesium stearate g, 13.61 g of starch, prepared by a conventional tablet preparation process.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
melting pointaaaaaaaaaa
Login to View More

Abstract

The invention discloses a new crystalline form of hydrochloric acid Ivabradine and a preparation method thereof. A mixture of the hydrochloric acid Ivabradine, methanol and acetone is heated to be completely dissolved, natural stewing is carried out for complete crystallization, and products are collected through filtration so as to obtain the new crystalline form of the hydrochloric acid Ivabradine.

Description

technical field [0001] The invention relates to a new crystal form of ivabradine hydrochloride and a preparation method thereof. Background technique [0002] Ivabradine and its addition salts with pharmaceutically acceptable acids, more particularly its hydrochloride, possess extremely valuable pharmacological and therapeutic properties, especially bradycardic properties, making these compounds For the treatment or prophylaxis of various clinical conditions of myocardial ischemia such as angina pectoris, myocardial infarction and related arrhythmias, as well as various pathological conditions involving arrhythmias, especially supraventricular arrhythmias and heart failure. [0003] The preparation and therapeutic use of ivabradine and its pharmaceutically acceptable acid addition salts, more particularly its hydrochloride, have been described in European patent specification EP 0534859. [0004] In view of the pharmaceutical value of this compound, it is of utmost importan...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D223/16
Inventor 王春霞卢文张志强
Owner BEIJING D VENTUREPHARM TECH DEV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com