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Nimesulide dry suspension and preparation method thereof

A dry suspension and sweetener technology, which is applied in anti-inflammatory agents, non-central analgesics, active ingredients of amides, etc., can solve problems affecting clinical application, inaccurate dosage, and inconvenient administration of divided doses, etc. To achieve the effect of convenient administration in divided doses, convenient administration and accurate dosage

Inactive Publication Date: 2010-07-14
HONGYI SCI & TECH CO LTD NANCHANG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although nimesulide oral preparations have been disclosed in the prior art, since the dosage of nimesulide for children is administered in kilograms of body weight, it is inconvenient for children to take divided doses of nimesulide preparations, and the dosage is inaccurate, which affects clinical practice. application
At present, there are no Nimesulide oral preparations produced by production packaging technology and equipment disclosed in the literature, especially Nimesulide dry suspension in double-packed bags that are convenient for divided doses and accurate in dosage.

Method used

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  • Nimesulide dry suspension and preparation method thereof
  • Nimesulide dry suspension and preparation method thereof
  • Nimesulide dry suspension and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Nimesulide 100g

[0030] Hypromellose 200g

[0031] Carboxymethyl Starch Sodium 100g

[0032] Stevia 8g

[0033] Flavor 2g

[0034] Micronized silica gel 50g

[0035] Mannitol 1000g

[0036]

[0037] Make 1000 bags

[0038] Preparation

[0039] Weigh Nimesulide, Hypromellose, Carboxymethyl Starch Sodium, Stevioside, Sweetener, Essence, Micropowder Silica Gel, Mannitol respectively according to the prescription ratio, mix them evenly, grind them, pass through a 30-40 mesh sieve, mix Evenly, put it in a new type of powder feeder, heat seal it with a double-packed heat sealer for powder packaging, and make a nimesulide dry suspension packaged in a double-packed bag.

Embodiment 2

[0041] Nimesulide 50g

[0042] Hypromellose 200g

[0043] Carboxymethyl Starch Sodium 100g

[0044] Stevia 8g

[0045] Flavor 2g

[0046] Micronized silica gel 50g

[0047] Mannitol 1000g

[0048]

[0049] Make 1000 bags

[0050] Preparation

[0051] Weigh Nimesulide, Hypromellose, Carboxymethyl Starch Sodium, Stevioside, Sweetener, Essence, Micropowder Silica Gel, Mannitol respectively according to the prescription ratio, mix them evenly, grind them, pass through a 30-40 mesh sieve, mix Evenly, put it in a new type of powder feeder, heat seal it with a double-packed heat sealer for powder packaging, and make a nimesulide dry suspension packaged in a double-packed bag.

Embodiment 3

[0053] Nimesulide 25g

[0054] Hypromellose 200g

[0055] Carboxymethyl Starch Sodium 100g

[0056] Stevia 8g

[0057] Flavor 2g

[0058] Micronized silica gel 50g

[0059] Mannitol 1000g

[0060]

[0061] Make 1000 bags

[0062] Preparation

[0063] Weigh Nimesulide, Hypromellose, Carboxymethyl Starch Sodium, Stevioside, Sweetener, Essence, Micropowder Silica Gel, Mannitol respectively according to the prescription ratio, mix them evenly, grind them, pass through a 30-40 mesh sieve, mix Evenly, put it in a new type of powder feeder, heat seal it with a double-packed heat sealer for powder packaging, and make a nimesulide dry suspension packaged in a double-packed bag.

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Abstract

The invention discloses a double-bag packaged nimesulide dry suspension. The double-bag packaged nimesulide dry suspension is prepared by the following steps: uniformly mixing 10 to 200 weight parts of nimesulide, 300 to 1,500 weight parts of filling agent, 100 to 500 weight parts of viscosity agent, 10 to 200 weight parts of flow aid, 5 to 10 weight parts of sweetener, and 1 to 3 weight parts of essence; crashing the mixture; screening the mixture with a screen of 30 to 40 meshes; mixing the mixture uniformly; placing the mixture in a novel powder feed device; and performing heat-sealing on the novel powder feed device with a powder-packing double-sealing device. Compared with the prior production technology, the nimesulide dry suspension prepared by the invention is convenient to administrate according to dose, has accuracy dose, and overcomes the defects that the quality is easy to change after single-bag package is unsealed and that the secondary pollution is easily caused by repeatedly sampling.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a nimesulide dry suspension and a preparation method thereof. Background technique [0002] Nimesulide is a non-steroidal anti-inflammatory drug used for the treatment of rheumatoid arthritis and osteoarthritis, respiratory inflammation, dysmenorrhea, surgical pain, fever and post-traumatic inflammation. It is characterized by high bioavailability and strong anti-inflammatory effect. It has multiple modes of anti-inflammatory effects, anti-platelet aggregation activity, low toxicity, high therapeutic index, and extremely low incidence of side effects. Also has analgesic and antipyretic effects. According to literature reports, 10 patients with rheumatoid arthritis took nimesulide 200mg, twice a day, most of the symptoms of the patients were relieved, and 9 of them were significantly improved. After 15 days of treatment, the stiffness in the morning, the degree of flu...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/18A61P29/00
Inventor 颜锋朱丹穆正义廖新华王晓霞刘孝乐
Owner HONGYI SCI & TECH CO LTD NANCHANG
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