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Medical application of garden balsam seed for preventing rheumatoid arthritis

A rheumatoid, acute sub-technology, applied in the treatment of rheumatoid arthritis, acute sub-field, can solve the problem of long-term use of toxic and side effects, can not prevent disease progression and other problems

Inactive Publication Date: 2010-07-21
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the treatment of RA is mainly based on drugs, including glucocorticoids, non-steroidal anti-inflammatory drugs (NSAIDs, such as diclofenac, aspirin, ibuprofen, etc.), disease-modifying antirheumatic drugs (DMARDs, such as methotrexate) DMARDs, gold salts, sulfasalazine, etc.), the former two can only relieve symptoms but cannot prevent the progression of the disease; the combined treatment of multiple DMARDs has become the mainstream of current RA treatment, but these drugs need long-term use and Toxic and side effects

Method used

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  • Medical application of garden balsam seed for preventing rheumatoid arthritis
  • Medical application of garden balsam seed for preventing rheumatoid arthritis
  • Medical application of garden balsam seed for preventing rheumatoid arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Preparation of total saponins extract from Acute subtilis

[0064] Weigh 20 kg of the acute sub-medicinal material, pulverize, add 10 times the amount of 70% ethanol, and extract under reflux at 100° C. for 3 times, each time for 3 hours. The extracts were combined to obtain extract A. Dissolve the extract A with an appropriate amount of distilled water, put it on a Diaion HP-20 macroporous resin column, elute with distilled water, 10%, 50%, 70%, and 95% ethanol respectively, combine the 50% ethanol eluents, and evaporate to dryness to obtain 968g of the total saponin extract of the acute seed, and the total saponin contained in the extract is 53.47%.

Embodiment 2

[0066] Preparation of total saponins extract from Acute subtilis

[0067] Weigh 20 kg of the acute sub-medicinal material, pulverize, add 12 times the amount of 95% ethanol, and extract at 90° C. for 3 times, each time for 3 hours. The extracts were combined to obtain extract A. Dissolve the extract A with an appropriate amount of distilled water, put it on a D-101 macroporous resin column, elute with distilled water, 30%, 50%, 60%, 70%, 80%, and 90% ethanol, and combine 50-70% ethanol The eluate was evaporated to dryness to obtain extract B, which was dissolved in methanol, mixed with diatomaceous earth, the ratio of diatomaceous earth to extract was 2:1, extracted three times with absolute ethanol under reflux, and the obtained extract The liquid was evaporated to dryness to obtain 792 g of the total saponins extract of the subtilis, and the total saponins contained in the extract reached 74.53%.

Embodiment 3

[0069] Preparation of total saponins extract from Acute subtilis

[0070] Weigh 25 kg of the acute sub-medicinal material, pulverize it, add 10 times the amount of 100% ethanol, and extract at 80° C. for 3 times, each time for 3 hours. The extracts were combined to obtain extract A. Dissolve the extract A in an appropriate amount of distilled water, put it on an AB-8 macroporous resin column, elute with distilled water, 30%, 50%, 70%, 80%, 90%, and 100% ethanol, and combine 50-100% ethanol The eluent was evaporated to dryness to obtain extract B. Dissolve the extract B in methanol, add diatomaceous earth and mix well, the ratio of diatomaceous earth to the extract is 2:1, extract 3 times with absolute ethanol under reflux, and evaporate the obtained extract to dryness to obtain 643g of total saponins extract , the extract contains 85.06% of total saponins.

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Abstract

The invention relates to the field of natural medicines, in particular to the medical application of garden balsam seed, i.e. the medical application of garden balsam seed for preventing rheumatoid arthritis. The pharmacological test shows that the garden balsam seed saponin has good application of preventing the rheumatoid arthritis. When the concentration is 30 mu mole / L, the garden balsam seed saponin can obviously restrain T lymphopoiesis induced by concanavalin A.

Description

technical field [0001] The invention relates to the field of natural medicines, in particular to the application of an acute rheumatoid for treating rheumatoid arthritis. Background technique [0002] Rheumatoid arthritis (rheumatoid arthritis, RA) is a chronic systemic autoimmune disease mainly characterized by joint lesions. Its pathogenesis is still unclear. It is clinically believed that the pathogenesis of RA is mainly due to autoimmune dysfunction in patients. , leading to inappropriate allergic reactions, degeneration of anti-inflammatory cells, deposition in joints, and joint tissue deformity and disability. According to investigations, the incidence of RA worldwide is about 1-2%. The total number of RA patients in my country has exceeded 4 million, and the incidence is still on the rise. [0003] At present, the treatment of RA is mainly based on drugs, including glucocorticoids, non-steroidal anti-inflammatory drugs (NSAIDs, such as diclofenac, aspirin, ibuprofen,...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P19/02A61P19/04A61P37/02
Inventor 李会军于俊杰李萍
Owner CHINA PHARM UNIV
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