ECG simulation data processing method based on true anatomical data of human body

A technology of real human body and anatomical data, applied in the direction of electrical digital data processing, special data processing applications, instruments, etc., can solve the problem of unable to quantitatively determine the electrophysiological characteristics of the heart

Inactive Publication Date: 2012-12-19
HARBIN INST OF TECH
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Problems solved by technology

[0005] The present invention provides an ECG simulation data processing method based on real human anatomical data in order to solve the problem of quantitatively determining cardiac electrophysiological characteristics in the prior art

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  • ECG simulation data processing method based on true anatomical data of human body
  • ECG simulation data processing method based on true anatomical data of human body
  • ECG simulation data processing method based on true anatomical data of human body

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specific Embodiment approach 1

[0019] Specific implementation mode 1. Combination Figure 10 Describe this embodiment, the ECG simulation data processing method based on real human body anatomy data, concrete process is as follows:

[0020] The ECG simulation data processing method based on real human anatomy data is characterized in that the specific process is as follows:

[0021] Step A, using the TNNP ventricular myocyte model, using real human heart anatomy data to establish a ventricular electrophysiological model;

[0022] The TNNP ventricular myocyte model is expressed as follows:

[0023] ∂ V m ∂ t = - I ion + ...

specific Embodiment approach 2

[0032] Embodiment 2. This embodiment is a further description of Step A in Embodiment 1. In Step A, the real human heart anatomy data is the "Visible Human Project" anatomical structure data set.

[0033] The US "Visible Human Project" (Visible Human Project) anatomical structure data set extracted the three-dimensional data of the left ventricle from the slice data of women, and selected a piece of left ventricle tissue with more information after layering along the Z-axis. Due to the electrical heterogeneity among ventricular myocytes, according to the anatomical proportion, we divide the ventricular wall into five layers from the inside to the outside along the direction of the myocardium: endocardium, inner transition layer, middle layer, outer transition layer, cardiac Adventitia.

specific Embodiment approach 3

[0034] Specific embodiment three. This embodiment is a further description of step A in specific embodiment one or two. In the case of myocardial ischemia, the following six physiological and pathological changes occur in the ventricle: local hypoxia, ATP level decline, The environment inside and outside the cell is acidified, the concentration of extracellular potassium ions increases, the concentration of intracellular sodium ions and calcium ions increases, and the concentration of extracellular sodium ions decreases; the six physiological and pathological changes are summarized as ATP-sensitive potassium current I K(ATP)Activation causes, the ventricular electrophysiological model established in step A is:

[0035] ∂ V m ∂ t = - ...

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Abstract

The invention relates to an ECG simulation data processing method based on true anatomical data of a human body, which belongs to an electrocardiogram simulation method, and solves the problem that cardiac electrophysiologic characteristics can not be determined quantitatively in the prior art. The method specifically comprises the following steps of: A, establishing a ventricular electrophysiological model by using a TNNP ventricular myocyte model and true cardiac anatomical data of human body; B, solving the ventricular electrophysiological model established in the step A to obtain the membrane potential Vm; C, obtaining the density rho of transmembrane voltage of all points in the time t medium corresponding to the source pole and according to the membrane potential Vm obtained in the step B, and drawing the ECG curve by taking time t as the transverse axis and the density rho of transmembrane voltage of all points in the time t medium corresponding to the source pole as a vertical axis. In the invention, based on the TNNP ventricular myocyte mode, true cardiac anatomical data of human body is used, the ventricular electrophysiological model is established, an auxiliary region is introduced to solve the membrane potential Vm, and the electrocardiogram is simulated.

Description

technical field [0001] The invention relates to an electrocardiogram simulation method. Background technique [0002] The heart is an important organ of the human body, and heart disease is one of the four major diseases that seriously threaten human health. According to the latest statistics from the Ministry of Health of the People's Republic of China, in 2008, the mortality rate of heart disease among urban residents in my country has risen from the third place in 2007 (behind malignant tumors and cerebrovascular diseases) to the second place (behind malignant tumors) , and still maintain an upward trend. Therefore, in-depth study of the mechanism of cardiac beating and understanding of the anatomical structure, electrophysiological and mechanical properties of the heart are of great significance for the prevention and treatment of heart diseases. Cardiology has become one of the most important fields of study in modern medicine. [0003] The heart is a complex system. ...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): G06F19/00
Inventor王宽全吕伟刚左旺孟袁永峰张恒贵
OwnerHARBIN INST OF TECH