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Preparation of cyanocobalamine and adenosine composition and preparation method thereof

A technology of adenosylcobalamin and pharmaceutical preparations, which is applied in the field of pharmaceutical preparations to achieve the effects of low production cost, rapid drug effect, and convenient carrying and taking

Active Publication Date: 2010-07-28
深圳市资福药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There is no report about the combination preparation of adenosylcobalamin and adenosine

Method used

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  • Preparation of cyanocobalamine and adenosine composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Made into 1000 pieces / grain

[0042] Preparation Process

[0043] Remarks: The following operations were all carried out under dark conditions.

[0044] a. take by weighing adenosylcobalamin, adenosine of prescription quantity, cross 80 mesh sieves,

[0045] b. Weigh the prescription amount of auxiliary materials and mix evenly, pass through an 80 mesh sieve and mix evenly.

[0046] c. Fully mix the excipients with adenosylcobalamin and adenosine in an incremental dilution method,

[0047] d. Granulating the mixture obtained in "c",

[0048] e. Press the granules obtained in "d" into tablets, and coat with a film to obtain a combined tablet of adenosylcobalamin and adenosine

[0049] Or compress the mixture obtained in "c" by direct powder compression method to obtain a combined tablet of adenosylcobalamin and adenosine

[0050] Or directly fill the granules obtained in "d" into hollow capsules to obtain a combination capsule of adenosylcobalamin and adenosine. ...

Embodiment 2

up to 1000ml

[0054] Made 1000 pieces

[0055] Preparation Process

[0056] Remarks: The following operations were all carried out under dark conditions.

[0057] a. Accurately weigh adenosylcobalamin and adenosine according to the prescription, add 70% to 90% of the prescribed amount of water for injection, stir until completely dissolved, add water for injection to the full amount, and control the pH value at 3.5-7.5;

[0058] b. Add 0.01% to 0.20% activated carbon to the solution obtained in "a", stir at 10°C to 60°C for 5min to 40min, filter for decarburization, and then filter through a 0.22μm microporous membrane until clear;

[0059] c. Measure the pH value and content of the solution obtained in "b". After passing the test, it is divided into 1000 ampoules, sealed, and sterilized by circulating steam at 100°C for 15 minutes to obtain a combined injection of adenosylcobalamin and adenosine, J , K, L.

[0060] d. Add 0.01% to 0.20% activated carbon to the so...

Embodiment 3

[0064] Made 1000 pieces

[0065] Preparation Process

[0066] Remarks: The following operations were all carried out under dark conditions.

[0067] a. Accurately weigh adenosylcobalamin, adenosine and auxiliary materials according to the prescription, add 70% to 90% of the prescribed amount of water for injection, stir until completely dissolved, add water for injection to the full amount, and control the pH value at 3.5-7.5;

[0068] b. Add 0.01% to 0.20% activated carbon to the solution obtained in "a", stir at 10°C to 60°C for 5min to 40min, filter for decarburization, and then filter through a 0.22μm microporous membrane until clear;

[0069] c. Measure the pH value and content of the solution obtained in "b". After passing the test, it is divided into 1000 vials, freeze-dried, and capped to obtain the combined injection freeze-dried preparation of adenosylcobalamin and adenosine.

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Abstract

The invention relates to the field of the pharmaceutical preparation, in particular to a cyanocobalamine and adenosine combined pharmaceutical preparation, and comprises an oral solid preparation, injection, a freeze-dried preparation for injection and a preparation method thereof. Each unit of pharmaceutical preparation of the invention comprises 0.05-5.0mg of cyanocobalamine and 0.05-5.0mg of adenosine, wherein the weight ratio of the cyanocobalamine and the adenosine is 1:10-10:1, and the preferential weight ratio is 1:5-5:1.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and specifically relates to a combined pharmaceutical preparation of adenosylcobalamin and adenosine, including oral solid preparations, injections, freeze-dried preparations for injections and preparation methods thereof. Background technique [0002] Adenosylcobalamin, English name: Cobamamide, chemical name: 5,6-dimethylimidazolyl-5`-deoxyadenosylcobalamin, is cyanocobalamin-type vitamin B 12 analogue of vitamin B 12 Metabolites in the body are vitamin B 12 One of the two active coenzyme forms in the body, it is a substance necessary for cell growth and proliferation and maintaining the integrity of nerve myelin sheath, compared with vitamin B 12 It has higher biological activity and bioavailability, can be directly absorbed and utilized by the human body, has strong activity, strong affinity with tissue cells, and slow excretion; it is an important coenzyme for synthesizing nucleo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/714A61K31/7076A61K9/08A61K9/19A61K9/20A61P7/06A61P25/00A61P3/02A61P7/00
Inventor 邵梅石秀伟
Owner 深圳市资福药业有限公司
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