Oblique rotational gravity mixed biological reaction equipment
A technology of biological reaction device and fixed device, which is applied in the direction of biochemical cleaning device, enzymology/microbiology device, bioreactor/fermentation tank combination, etc. problems, to achieve the effect of easy cell culture and simple operation
Active Publication Date: 2012-06-13
博晖生物制药股份有限公司
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Problems solved by technology
[0003] Due to the disadvantages of traditional spinner bottle culture, such as heavy labor, a large number of bottles, easy contamination of microorganisms, high energy consumption, and a lot of dirt, microcarrier cell culture technology has attracted increasing attention.
Imported bioreactors are expensive, while domestic bioreactors are cheaper, and the cultivation effect and stability are not guaranteed.
Method used
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[0015] In order to make the features and advantages of the present invention more comprehensible, the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.
[0016] figure 1 , figure 2 In order to realize the side view of the two models of this design idea, the crossbeam (4) in the frame (1) is connected with one or more rows, one or more columns parallel to each other and 5 to 80 degrees from the horizontal plane. angular columnar culture vessel fixtures (3), each column or row of columnar culture vessel fixtures (3) connected by a belt or gear (5) and connected to a common motor (2) via a belt or gear (6), The motor is controlled by the control circuit to drive the rotation.
[0017] image 3 It is a front view of a horizontally placed columnar culture vessel fixing device, and two, three or more sets of fixing holes (7) for placing columnar culture vessels are symmetrically arranged around the...
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The invention relates to oblique rotational gravity mixed biological reaction equipment, in particular to biological reaction equipment capable of enabling a container with a columnar main body to perform micro-carrier cell culture. In a frame which plays a role in fixing and supporting, a plurality of columnar culture vessel fixing devices which are parallel to one another and form angles of between 5 and 8 degrees with a horizontal plane are driven by an electric motor to rotate; a plurality of groups of fixing hole sites are symmetrically distributed around rotating shafts on the columnar culture vessel fixing devices and relatively to the centers of the rotating shafts; each group of hole sites consists of at least two fixing holes with centers on the same straight line and parallel planes and a supporting pedestal which has a supporting effect at the bottom; the lines or rows of columnar culture vessel fixing devices, the lines or rows of columnar culture vessel fixing devices and the electric motor can be driven by a transmission belt or a gear; the reaction equipment can comprise a control circuit part; and the reaction equipment can be accommodated in a small-sized temperature control vessel or arranged in a temperature control chamber.
Description
technical field [0001] Microcarrier cell culture is the main method of large-scale cell culture. Conventional bioreactors for microcarrier cell culture are expensive and complex in structure, requiring professional operators to use them. [0002] The bioreaction device involved in the invention is economical and practical, and the operation is simple, so that the microcarrier cell culture is as easy as the common cell flask cell culture. Background technique [0003] Due to the disadvantages of traditional spinner bottle culture, such as heavy labor, a large number of bottles, easy contamination of microorganisms, high energy consumption, and a lot of dirt, microcarrier cell culture technology has attracted increasing attention. Imported bioreactors are expensive, while domestic bioreactors are cheaper, and the cultivation effect and stability are not guaranteed. Contents of the invention [0004] In order to solve the above-mentioned problems, the present invention provi...
Claims
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IPC IPC(8): C12M3/00C12M1/36
CPCC12M23/46C12M27/12
Inventor 杨国松
Owner 博晖生物制药股份有限公司