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Preparation method of Chinese pulsatilla root submicron powder at normal temperature

A technology of Pulsatilla officinalis powder and superfine powder, which is applied in the directions of medical preparations containing active ingredients, powder delivery, pharmaceutical formulations, etc., can solve problems such as affecting the quality and therapeutic effect of traditional Chinese medicine, insufficient release of active ingredients, poor appearance quality and palatability, etc. , to achieve the effect of improving cell wall breaking rate and bioavailability, saving medicinal materials, and controllable quality standards

Inactive Publication Date: 2010-08-25
HENAN KANGXING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The 2005 edition of "The Veterinary Pharmacopoeia of the People's Republic of China" contains the preparations composed of Pulsatilla pulsatillae powder, chicken coccidia powder, Jililing tablets, Jililingsan, Chulijing, Qiqingbaidu granules, Bailongsan, etc. , mainly used for the treatment of heat-toxin bloody dysentery, piglet pullorum, chick pullorum, etc. Among them, Pulsatilla powder is derived from the Pulsatilla decoction prescription in Zhang Zhongjing's "Treatise on Febrile Diseases" in the Han Dynasty. Good effect, but there are many shortcomings, 1. Coarse powder, the particle size is 250-850 microns, 2. Large dosage, 150-250g for horses and cattle, 30-45g for sheep and pigs, 3. Poor appearance quality and palatability , coptis and Phellodendron have a very strong bitter taste, so that animals do not like to eat
4. The active ingredients cannot be fully released, and the bioavailability is low, which seriously affects the quality and therapeutic effect of traditional Chinese medicine, and restricts its clinical application

Method used

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Effect test

Embodiment 1

[0043] The preparation method of Pulsatillae powder superfine powder of the present invention, the whole preparation process is all carried out at normal temperature, and its steps are as follows:

[0044] The first step, drug selection: select Chinese herbal medicines Pulsatilla 6kg, Coptidis 3kg, Phellodendron 4.5kg, Qinpi 6kg, wash, dry, cut into 3-5cm long sections for later use;

[0045] Step 2, Coarse Powder: Grind the cut pieces of Chinese herbal medicine into medium powder with a Shibata-style pulverizer, pass through a 65-mesh sieve, the particle size of the powder is 180-250 μm, and control the amount of powder passing through the 80-mesh sieve to not exceed 60% ;

[0046] The third step, mixing: after preliminary mixing of the above-mentioned powders, place them in a tank mixer and mix continuously for more than 0.5 hours to obtain a mixed powder with uniform mixing and uniform color;

[0047] The fourth step, fine powder: grind the mixed powder obtained in the thi...

Embodiment 2

[0051] The preparation method of Pulsatillae powder superfine powder of the present invention, the whole preparation process is all carried out at normal temperature,

[0052] The steps are as follows:

[0053] The first step, drug selection: select Chinese herbal medicines Pulsatilla 12kg, Coptidis 6kg, Phellodendron 9kg, Qinpi 12kg, wash, dry, cut into 3-5cm long sections for later use;

[0054] Step 2, Coarse Powder: Grind the cut pieces of Chinese herbal medicine into medium powder with a Shibata-style pulverizer, pass through a 65-mesh sieve, the particle size of the powder is 180-250 μm, and control the amount of powder passing through the 80-mesh sieve to not exceed 60% ;

[0055] The third step, mixing: after preliminary mixing of the above-mentioned powders, place them in a tank mixer and mix continuously for more than 0.5 hours to obtain a mixed powder with uniform mixing and uniform color;

[0056] The fourth step, fine powder: grind the mixed powder obtained in t...

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Abstract

The invention discloses a preparation method of Chinese pulsatilla root submicron powder at normal temperature. The method comprises the following steps of: selecting the following components in parts by weight: 4 parts of Chinese pulsatilla root, 2 parts of coptis chinensis, 3 parts of golden cypress and 4 parts of ash bark; cleaning and airing; cutting into 3-5cm segments for standby; coarse powder preparation: pulverizing the segmented traditional Chinese medicine tablets and sieving on a sieve of 65 meshes; mixing: uniformly mixing obtained powder; fine powder preparation: pulverizing the mixing powder into fine powder and sieving on a sieve of 100 meshes; and submicron powder preparation: pulverizing the fine powder into submicron powder, wherein the grain size of the powder is 20-40 micrometers. The preparation method is carried out at normal temperature, and low-temperature or special conditions are not needed for preparing; after the raw material medicines are pulverized into the submicron powder, the cell wall-broken rate and the bioavailability are improved, and the pharmacological action is enhanced; the drug dose is reduced, and medicinal materials are saved; the submicron powder can be directly used for drinking water; and the preparation process is simple, the quality standard is controllable, thus the preparation method meets the requirement of mass production.

Description

technical field [0001] The invention relates to a veterinary drug, in particular to a method for preparing the veterinary drug Pulsatillae San at room temperature. Background technique [0002] Chinese herbal medicine is a cultural treasure of our country. The world's first book related to natural medicine is my country's "Shen Nong's Herbal Classic", which records 365 kinds of natural medicines. my country has a vast territory, spanning cold, warm and hot zones, and is rich in medicinal plant resources. There are more than 13,000 kinds of Chinese herbal medicines. It is one of the countries with the largest variety of wild medicinal plants, the earliest utilization and the highest utilization rate in the world. One, has accumulated rich experience in the use of Chinese herbal medicine. Chinese herbal medicine has incomparable advantages over other chemically synthesized drugs in the prevention and treatment of diseases: high safety, less toxic and side effects, more active ...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61K9/14A61P1/12
Inventor 张国祖陈献忠于瑞李荣誉马仲彬
Owner HENAN KANGXING PHARMA
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